672956-75-1

Usage

Uses

Used in Pharmaceutical Industry:
2,6-BIS(2,2,2-TRIFLUOROACETYL)CYCLOHEXANONE is used as a reactant in the synthesis of fluorinated pyrrolopyridine and pyrrolopyrimidine nucleosides for their potential applications in medicinal chemistry. These nucleosides may exhibit unique biological activities and therapeutic properties, making them valuable candidates for the development of new drugs and treatments.
Used in Chemical Research:
In the field of chemical research, 2,6-BIS(2,2,2-TRIFLUOROACETYL)CYCLOHEXANONE is utilized as a starting material or intermediate in the synthesis of complex organic molecules and compounds. Its reactivity and structural features allow for the exploration of new chemical reactions and the creation of novel molecules with potential applications in various industries.

Upstream product

• 431-47-0 trifluoroacetic acid-methyl ester 
• 108-94-1 cyclohexanone 
• 383-63-1 ethyl trifluoroacetate, 

Downstream Products

• 935700-08-6 cis-2,6-dibromo-2,6-bis(trifluoroacetyl)cyclohexanone 

Relevant academic research and scientific papers

2,4-Bridged 1,5-bis(fluoroalkyl)-1,3,5-triketones: Synthesis and properties

Symmetrical and unsymmetrical bis-fluoroacylcyclopentanones and cyclohexanones were synthesized. NMR data reveal that the keto-enol tautomeric equilibrium is changed markedly by the presence of a trimethylene bridge compared to an ethylene moiety. A considerable influence of the fluoroalkyl chain length was found for 2,6-(bisfluoroacyl)cyclohexanones.

Lithium sulfur battery

A lithium sulfur battery comprising an electrolyte solvent which comprises at least one fluorosubstituted compound is described. Preferred fluorosubstituted compounds which are predominantly solvents are notably selected from the group consisting of fluorosubstituted carboxylic acid esters, fluorosubstituted carboxylic acid amides, fluorosubstituted fluorinated ethers, fluorosubstituted carbamates, fluorosubstituted cyclic carbonates, fluorosubstituted acyclic carbonates, fluorosubstituted ethers, perfluoroalkyl phosphoranes, fluorosubstituted phosphites, fluorosubstituted phosphates, fluorosubstituted phosphonates, and fluorosubstituted heterocycles. Monofluoroethylene carbonate, cis-difluoroethylene carbonate, trans-difluoroethylene carbonate, 4,4-difluoroethylene carbonate, trifluoroethylene carbonate, tetrafluoroethylene carbonate, 4-fluoro-4-methyl-1,3-dioxolane-2-one, 4-fluoro-4-ethyl-1,3-dioxolane-2-one, 2,2,2-trifluoroethyl-methyl carbonate, 2,2,2-trifluoroethyl-fluoromethyl carbonate are preferred. The solvent may further comprise a non-fluorinated solvent, e.g., ethylene carbonate, a dialkyl carbonate, or propylene carbonate. Use of such fluorinated compound as additive for such batteries and specific electrolyte solutions.

Aromatization via a dibromination-double dehydrobromination sequence: A facile and convenient synthetic route to 2,6-bis(trifluoroacetyl)phenols

An efficient and reliable method to synthesize 2,6-bis(trifluoroacetyl) phenols bearing various substituents in the 4-po-sition was developed. These valuable fluorinated building blocks were obtained from the corresponding cyclohexanones in a facile and convenient procedure, demonstrated to be superior to the traditional approaches. The application of this methodology to cyclohex-ane-1,4-dione opened access to 2,5-bis(polyfluoroacyl)-1,4- hydroquinones. Structural peculiarities of the obtained phenols as well as their 1,3-dicarbonyl or 1,3,5-tricarbonyl precursors are discussed on the basis of multinuclear NMR spectroscopy.