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673-05-2

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673-05-2 Usage

General Description

2-Pyridineacetic acid hydrazide, also known as 2-Pyridylhydrazine, is a chemical compound with the molecular formula C7H8N4O. It is generally used as a reagent in the synthesis of pharmaceutical compounds and agrochemicals. The compound is also used as a chelating agent for metal ions in analytical chemistry and as a corrosion inhibitor in the oil and gas industry. Additionally, it has been studied for its potential use as a therapeutic agent in the treatment of neurological disorders and as a radiation protectant. 2-Pyridineacetic acid hydrazide is a white to off-white solid that is soluble in water and organic solvents, and it should be handled and stored with appropriate safety precautions due to its potential health hazards.

Check Digit Verification of cas no

The CAS Registry Mumber 673-05-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,7 and 3 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 673-05:
(5*6)+(4*7)+(3*3)+(2*0)+(1*5)=72
72 % 10 = 2
So 673-05-2 is a valid CAS Registry Number.

673-05-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Pyridin-2-ylacetohydrazide

1.2 Other means of identification

Product number -
Other names pyridine-2-yl-acetic acid hydrazide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:673-05-2 SDS

673-05-2Downstream Products

673-05-2Relevant articles and documents

Synthesis and biological activities of ethyl 2-(2-pyridylacetate) derivatives containing thiourea, 1,2,4-triazole, thiadiazole and oxadiazole moieties

Szulczyk, Daniel,Tomaszewski, Piotr,Jó?wiak, Micha?,Kozio?, Anna E.,Lis, Tadeusz,Collu, David,Iuliano, Filippo,Struga, Marta

, (2017)

Thirty six novel heterocyclic derivatives of ethyl 2-(2-pyridylacetate) were efficiently synthesized. The new compounds involve the linkage of a 2-pyridyl ring with thiosemicarbazide (compounds 1-7), 1,2,4-triazole (compounds 1a-7a), 1,3,4-thiadiazole (compounds 1b-7b), and 1,3,4-oxadiazole (compounds 1f-7f) moieties. The last group of compounds 1e-7e involves the connection of a 2-pyridyl ring with 1,2,4-triazole and thiourea. 1H-NMR, 13C-NMR and MS methods were used to confirm the structures of the obtained derivatives. The molecular structures of 3, 3b, 7a and 7f were further confirmed by X-ray crystallography. All obtained compounds were tested in vitro against a number of microorganisms, including Gram-positive cocci, Gram-negative rods and Candida albicans. In addition, the obtained compounds were tested for cytotoxicity and antiviral activity against HIV-1.

COMBINATION THERAPY COMPRISING A2A/A2B AND PD-1/PD-L1 INHIBITORS

-

Page/Page column 81-82, (2021/07/10)

The present application provides methods of treating cancer using a combination of an inhibitor of A2A and/or A2B and an inhibitor of PD-1 and/or PD-L1.

Synthesis and structural study of some N-acyl-4-allylsemicarbazides and the product of their cyclization with a potential antimicrobial activity

Drozd, Monika,Ginalska, Grazyna,Karczmarzyk, Zbigniew,Kowalczuk, Dorota,Morawiak, Maja,Pitucha, Monika,Swatko-Ossor, Marta,Urbanczyk-Lipkowska, Zofia,Wysocki, Waldemar

, (2020/06/21)

In this paper semicarbazide (2a-2h) and 1,2,4-trazole (3a-3h) derivatives with allyl group were synthesized. All compounds were tested in vitro for their antimicrobial activity showing different activity to E. coli, S. aureus, S. epidermidis, M. smegmatis, M. phlei and M. tuberculosis H37Ra. The antimicrobial activity is showed 2g against S. epidermidis, 3g against E. coli and S. epidermidis and 3h against E. coli. The crystal structure of determinations of 2b, 2d, 3b, 3c and 3e were undertaken in order to confirm the synthesis pathway and identification of their tautomeric forms in the crystalline state. Theoretical calculations showed that the physico-chemicals (logP) and electronic properties (MEP distribution, energy localization of HOMO and LUMO orbitals) are related to observed antimicrobial activity of investigated compounds. The molecular docking study carried out for the most active against M. tuberculosis compound 3b using the M. tuberculosis cytochrome P450 CYP121 showed that this compound binds to the active site of P450 by hydrogen bonds via water molecule with the amino acid residue of Met86A and molecule of hem.

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