67304-39-6

Basic information

• Product Name: 2-(octadecylsulfanyl)naphthalene-1,4-dione
• CAS NO: 67304-39-6
• Molecular Formula: C₂₈H₄₂O₂S
• Molecular Weight: 442.6969
• Mol File: 67304-39-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 554°C at 760 mmHg
• Flash Point: 213.8°C
• Density: 1.02g/cm³
• Vapor Pressure: 2.58E-12mmHg at 25°C
• Refractive Index: 1.537
• CAS DataBase Reference: 2-(octadecylsulfanyl)naphthalene-1,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(octadecylsulfanyl)naphthalene-1,4-dione(67304-39-6)
• EPA Substance Registry System: 2-(octadecylsulfanyl)naphthalene-1,4-dione(67304-39-6)

Safety Data

• Hazardous Substances Data: 67304-39-6(Hazardous Substances Data)

Usage

Type of compound

Derivative of anthraquinone

Structure

Long hydrocarbon chain attached to a naphthalene-1,4-dione core

Usage

Organic synthesis, dye precursor

Potential applications

Biomedical and pharmaceutical industries due to interesting chemical structure and potential biological activities.

Upstream product

• 2885-00-9 Octadecanethiol 
• 130-15-4 [1,4]naphthoquinone 

Relevant articles and documents

Synthesis of a novel series of 2-alkylthio substituted naphthoquinones as potent acyl-CoA: Cholesterol acyltransferase (ACAT) inhibitors

We report a new series of naphthoquinone derivatives as potent ACAT inhibitors, which were obtained through structural variations of previously disclosed lead 1. Several analogs represented by 3i-l, 4k-m, 6a-n, 7a, and 7i demonstrated potent human macrophage ACAT inhibitory activity by a cell-based reporter assay with human HepG2 cell lines. In particular, compounds 4l and 6j emerged as highly potent inhibitors, exhibiting significantly high inhibitory potencies with IC50 values of 0.44 μM and 0.6 μM, respectively. Moreover, compound 4l significantly reduced the accumulation of cellular cholesterol in HepG2 cell lines.