67318-11-0

Basic information

• Product Name: 2-Thiophenecarboxylic acid, 5-amino-, ethyl ester
• CAS NO: 67318-11-0
• Molecular Formula: C7H9NO2S
• Molecular Weight: 171.22
• Mol File: 67318-11-0.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 2-Thiophenecarboxylic acid, 5-amino-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Thiophenecarboxylic acid, 5-amino-, ethyl ester(67318-11-0)
• EPA Substance Registry System: 2-Thiophenecarboxylic acid, 5-amino-, ethyl ester(67318-11-0)

Safety Data

• Hazardous Substances Data: 67318-11-0(Hazardous Substances Data)

Upstream product

• 133719-49-0 ethyl 5-[(tert-butoxycarbonyl)amino]thiophene-2-carboxylate 
• 352530-37-1 5-(ethoxycarbonyl)thiophene-2-ylzinc bromide 
• 2810-04-0 Ethyl thiophene-2-carboxylate 
• 6317-37-9 5-nitrothiophene-2-carboxylic acid 
• 527-72-0 2-thiophenylcarboxylic acid 
• 5751-84-8 5-nitro-2-thiophenecarboxylic acid ethyl ester 

Downstream Products

• 112889-02-8 N-(5-methylamino-2-thiophenecarbonyl)-L-glutamic acid diethyl ester 
• 112887-68-0 N-[5-[N-[(3,4-dihydro-2-methyl-4-oxy-6-quinazolinyl)-methyl]-N-methylamino]-2-thenoyl]-L-glutamic acid 
• 132463-02-6 N-[[5-[N-(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-methyl]amino-2-thiophenecarbonyl]-L-glutamic acid diethyl ester 
• 929032-62-2 Ethyl 5-[(phenylmethyl)amino]-2-thiophenecarboxylate 
• 929032-61-1 ethyl 5-[bis(phenylmethyl)amino]-2-thiophenecarboxylate 

Relevant articles and documents

Aromatic C-H amination in hexafluoroisopropanol

We report a direct radical aromatic amination reaction that provides unprotected anilines with an improvement in the substrate scope compared to prior art. Hydrogen bonding by the solvent hexafluoroisopropanol to anions of cationic species is responsible for increased reactivity and can rationalize the enhancement in substrate scope. Our findings may have bearings on radical additions to arenes for direct C-H functionalization in general.

Design, synthesis, and biological evaluation of 2-(phenoxyaryl)-3-urea derivatives as novel P2Y1 receptor antagonists

A novel series of 2-(phenoxyaryl)-3-urea derivatives were designed, synthesized, and biologically evaluated for their anti-thrombotic activity. Most of compounds exhibited good inhibition against P2Y1 receptor. Among them, three compounds 11, 12, and 13 demonstrated good P2Y1 receptor antagonistic potency in vitro (IC50 = 0.62 μM, 0.82 μM, and 0.21 μM, respectively). In antiplatelet aggregation study, four compounds 2, 3, 9, and 13 showed good antiplatelet activity. The possible binding modes of compounds with P2Y1 receptor were also explored by molecular docking simulation. The docking studies demonstrated that compound 13 interacted well with Phe119 through hydrophobic interaction and modestly improved the P2Y1 receptor antagonistic activity, making it justifiable for further investigation.

Non-deprotonative primary and secondary amination of (hetero)arylmetals

Herein we disclose a novel method for the facile transfer of primary (-NH2) and secondary amino groups (-NHR) to heteroaryl-as well as arylcuprates at low temperature without the need for precious metal catalysts, ligands, excess reagents, protecting and/or Erecting groups. This one-pot transformation allows unprecedented functional group tolerance and it is wellsuited for the amination of electron-rich, electron-deficient as well as structurally complex (hetero)arylmetals. In some of the cases, only catalytic amounts of a copper (l) salt is required.