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Cholesterol hydrogen phthalate is a chemical compound derived from cholesterol, an essential component of cell membranes and a precursor for hormone and vitamin D synthesis. It is a phthalate ester with a hydrogen atom replacing one of the alcohol groups of cholesterol and a phthalate group attached. This unique structure endows it with various properties, making it a versatile compound in pharmaceutical and industrial applications.

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  • 6732-01-0 Structure
  • Basic information

    1. Product Name: CHOLESTEROL HYDROGEN PHTHALATE
    2. Synonyms: PHTHALIC ACID MONOCHOLESTEROL ESTER;5-CHOLESTEN-3-BETA-OL HYDROGEN PHTHALATE;CHOLESTEROL HYDROGEN PHTHALATE;CHOLESTERYL HYDROGEN PHTHALATE;cholest-5-en-3beta-yl hydrogen phthalate;Phthalic acid 1-(3β-cholesteryl) ester;Phthalic acid hydrogen 1-(3β-cholesteryl) ester;Phthalic acid hydrogen 1-(3β-cholest
    3. CAS NO:6732-01-0
    4. Molecular Formula: C35H50O4
    5. Molecular Weight: 534.77
    6. EINECS: 229-783-9
    7. Product Categories: Cholesteryl Compounds (Liquid Crystals);Functional Materials;Liquid Crystals & Related Compounds
    8. Mol File: 6732-01-0.mol
  • Chemical Properties

    1. Melting Point: 163 °C
    2. Boiling Point: 631.8°C at 760 mmHg
    3. Flash Point: 191.8°C
    4. Appearance: /
    5. Density: 1.11g/cm3
    6. Vapor Pressure: 7.89E-17mmHg at 25°C
    7. Refractive Index: 1.561
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. PKA: 3.36±0.36(Predicted)
    11. CAS DataBase Reference: CHOLESTEROL HYDROGEN PHTHALATE(CAS DataBase Reference)
    12. NIST Chemistry Reference: CHOLESTEROL HYDROGEN PHTHALATE(6732-01-0)
    13. EPA Substance Registry System: CHOLESTEROL HYDROGEN PHTHALATE(6732-01-0)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 6732-01-0(Hazardous Substances Data)

6732-01-0 Usage

Uses

Used in Pharmaceutical Applications:
Cholesterol hydrogen phthalate is used as a solubility enhancer for poorly water-soluble drugs, improving their dissolution and bioavailability. Its amphiphilic nature allows it to form micelles and mixed micelles with other surfactants, facilitating drug absorption and distribution.
Used in Drug Delivery Systems:
Cholesterol hydrogen phthalate serves as a drug delivery vehicle, enabling targeted and controlled drug release. It can be incorporated into various drug delivery systems, such as nanoparticles, liposomes, and hydrogels, to enhance the therapeutic efficacy and minimize side effects of drugs.
Used in Plasticizer Applications:
As a plasticizer, cholesterol hydrogen phthalate is used to increase the flexibility and workability of various materials, such as polymers and resins. Its compatibility with a wide range of polymers makes it suitable for use in the manufacturing of flexible films, coatings, and adhesives.
Used in Photodynamic Therapy:
Cholesterol hydrogen phthalate is under investigation for its potential use as a photodynamic therapy agent for cancer treatment. Its ability to absorb light and generate reactive oxygen species upon irradiation makes it a promising candidate for targeted cancer therapy.
Used in Cosmetics Industry:
In the cosmetics industry, cholesterol hydrogen phthalate is used as an emollient and skin conditioning agent. Its ability to form complexes with other ingredients and improve skin hydration and elasticity makes it a valuable component in various cosmetic formulations.
Used in Research Applications:
Cholesterol hydrogen phthalate is also used in research settings to study the interactions between cholesterol and other biomolecules, as well as to investigate the effects of phthalate esters on biological systems.

Check Digit Verification of cas no

The CAS Registry Mumber 6732-01-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,7,3 and 2 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 6732-01:
(6*6)+(5*7)+(4*3)+(3*2)+(2*0)+(1*1)=90
90 % 10 = 0
So 6732-01-0 is a valid CAS Registry Number.
InChI:InChI=1/C35H50O4/c1-22(2)9-8-10-23(3)29-15-16-30-28-14-13-24-21-25(17-19-34(24,4)31(28)18-20-35(29,30)5)39-33(38)27-12-7-6-11-26(27)32(36)37/h6-7,11-13,22-23,25,28-31H,8-10,14-21H2,1-5H3,(H,36,37)/t23-,25+,28+,29-,30+,31+,34+,35-/m1/s1

6732-01-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name Cholesterol Hydrogen Phthalate

1.2 Other means of identification

Product number -
Other names CHOLESTEROL HYDROGEN PHTHALATE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:6732-01-0 SDS

6732-01-0Downstream Products

6732-01-0Relevant articles and documents

Connector type-controlled mesophase structures in poly(propyl ether imine) dendritic liquid crystals of identical dendrimer generations

Kumar, Prabhat,Shankar Rao,Krishna Prasad,Jayaraman, Narayanaswamy

, p. 3665 - 3678 (2017)

Poly(propyl ether imine) (PETIM) dendrimers of one to three generations are used as dendritic cores to identify the influence of varying connector types that connect the dendritic core with peripheral mesogens on the emerging liquid crystalline (LC) properties. The LC properties vary in these dendritic liquid crystals, even when the dendrimer generations and thus the number of peripheral mesogenic moieties remain identical. PETIM dendrimer generations one to three, ester and amide connectors varying with succinates, phthalates, and succinamides, are studied herein. Cholesteryl moieties are installed at the peripheries through the above connectors to induce mesogenic properties. These modified dendritic liquid crystals reveal a layered mesophase structure in most ester and amide connector-derivatives, whereas a third-generation phthalate ester dendrimer favors a rectangular columnar mesophase structure. A transition from layered to a rectangular columnar structure results by a mere change in the connector varying between a succinate or succinamide or phthalate, within one particular dendrimer generation and without altering the underlying dendrimer core or the number of mesogenic moieties. The study demonstrates that in dendritic liquid crystals with essentially identical chemical constitutions, a change in the connector type connecting the mesogen with the dendrimer core is sufficient to change the mesophase structures.

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