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Usage

Uses

Used in Pharmaceutical Industry:
(2-Bromo-benzyl)-ethyl-amine is used as a starting material for the synthesis of various drugs. Its unique structure and functional groups make it a valuable component in the development of new pharmaceutical compounds.
Used in Agrochemical Industry:
(2-Bromo-benzyl)-ethyl-amine is used as a building block in the production of various agrochemicals. Its versatility in organic synthesis allows it to be incorporated into a wide range of agrochemical products.
Used in Organic Synthesis:
(2-Bromo-benzyl)-ethyl-amine is used as a valuable precursor in the synthesis of various aromatic compounds. Its bromine atom and aromatic properties make it an important synthetic tool in the production of a wide variety of organic compounds.

InChI:InChI=1/C9H12BrN/c1-2-11-7-8-5-3-4-6-9(8)10/h3-6,11H,2,7H2,1H3

Upstream product

• 75-04-7 ethylamine 
• 3433-80-5 1-Bromo-2-bromomethyl-benzene 
• 6630-33-7 ortho-bromobenzaldehyde 

Downstream Products

• 146983-00-8 N-Ethyl-N-(2-bromobenzyl)-1-cyclopentenylamine 
• 287199-79-5 N-(2-bromo-benzyl)-2-(2-cyano-1-methyl-1H-indol-3-yl)-N-ethyl-acetamide 
• 146982-98-1 N-Ethyl-N-(2-bromobenzyl)-1-cyclohexenylamine 

Relevant academic research and scientific papers

NEW CRTH2 ANTAGONISTS

The present invention relates to compounds of formula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by CRTh2 antagonist activity.

New CRTh2 antagonists

The present invention relates to compounds of formula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by CRTh2 antagonist activity.

Aryl Radical Cyclizations onto Enamine Double Bonds

Aryl radicals from N-alkyl-N-(2-bromobenzyl)-1-cyclohexenylamine 2 and N-alkyl-N-(2-bromobenzyl)cyclopentenylamine 11 cyclize readily onto the enamine double bond by 6-endo and 5-exo closure.In the case of 2, 6-endo cyclization is the major pathway; however, the 6-endo to 5-exo ratio is dependent upon the N-alkyl substituent.In both cases, the dominant isomer from 6-endo cyclization is the cis isomer.For 2a in toluene, values of k6-endo and k5-exo at 80 deg C were 4.6 x 108 s-1 and 1.5 x 108 s-1, respectively.

Benzylamines: Synthesis and evaluation of antimycobacterial properties

The synthesis of benzylamines with various N-alkyl chains and substituents in the aromatic system as well as their evaluation on Mycobacterium tuberculosis H 37 Ra are described. The most active compounds in this test, N-methyl-3-chlorobenzylamine (MIC 10.2 μg/mL), N-methyl-3,5-dichlorobenzylamine (93, MIC 10.2 μg/mL), and N-butyl-3,5-difluorobenzylamine (MIC 6.4 μg/mL), also exhibited a marked inhibitory effect on Mycobacterium marinum and Mycobacterium lufu used for the determination of antileprotic properties. The combination of 93 with aminosalicylic acid, streptomycin, or dapsone exert marked supra-additive effects on M. tuberculosis H 37 Ra.