67345-78-2

Usage

Uses

Used in Pharmaceutical and Agricultural Chemical Synthesis:
2-Chloro-4-nitrobenzhydrazide is used as a reagent for the synthesis of various pharmaceuticals and agricultural chemicals, leveraging its strong oxidizing properties to facilitate chemical reactions in the production process.
Used in Dye and Pigment Production:
2-CHLORO-4-NITROBENZHYDRAZIDE is utilized as a precursor in the manufacturing of dyes and pigments, contributing to the coloration and stability of these products.
Used in Anticancer and Antimicrobial Applications:
2-Chloro-4-nitrobenzhydrazide is investigated for its potential use in the treatment of certain types of cancer and infectious diseases, due to its antimicrobial and cytotoxic properties, which can target and inhibit the growth of disease-causing agents.
Used in Chemical Oxidation Processes:
In the field of organic chemistry, 2-Chloro-4-nitrobenzhydrazide is employed as an oxidizing agent, enabling the oxidation of various organic compounds, which is crucial for the synthesis of a wide range of chemical products.

InChI:InChI=1/C7H6ClN3O3/c8-6-3-4(11(13)14)1-2-5(6)7(12)10-9/h1-3H,9H2,(H,10,12)

Upstream product

• 13324-11-3 methyl 2-chloro-4-nitrobenzoate 
• 73097-02-6 ethyl 2-chloro-4-nitrobenzoate 

Downstream Products

• 1296644-69-3 C₂₄H₂₀Cl₂N₆O 
• 1296644-68-2 C₂₁H₂₀Cl₂N₄O 
• 1296644-67-1 C₁₉H₁₈Cl₂N₄ 
• 1296644-92-2 C₁₉H₁₆Cl₂N₄O₂ 
• 80014-91-1 diethyl N-(2-chloro-4-nitrobenzoyl)-L-glutamate 

Relevant academic research and scientific papers

SUBSTITUTED THIAZOLO-PYRIDINE COMPOUNDS AS MALT1 INHIBITORS

Disclosed are compounds of the general formula (I), wherein R1-R3 are as defined herein, for use as MALT1 inhibitors in the treatment of autoimmune and inflammatory diseases or disorders. Methods of synthesizing the compounds are also disclosed. Also disc

Rational design, synthesis and biological evaluation of 1,3,4-oxadiazole pyrimidine derivatives as novel pyruvate dehydrogenase complex E1 inhibitors

On the basis of previous study on 2-methylpyrimidine-4-ylamine derivatives I, further synthetic optimization was done to find potent PDHc-E1 inhibitors with antibacterial activity. Three series of novel pyrimidine derivatives 6, 11 and 14 were designed and synthesized as potential Escherichia coli PDHc-E1 inhibitors by introducing 1,3,4-oxadiazole-thioether, 2,4-disubstituted-1,3-thiazole or 1,2,4-triazol-4-amine-thioether moiety into lead structure I, respectively. Most of 6, 11 and 14 exhibited good inhibitory activity against E. coli PHDc-E1 (IC50 0.97-19.21 μM) and obvious inhibitory activity against cyanobacteria (EC50 0.83-9.86 μM). Their inhibitory activities were much higher than that of lead structure I. 11 showed more potent inhibitory activity against both E. coli PDHc-E1 (IC50 50 50 = 0.97 μM) and cyanobacteria (EC50 = 0.83 μM). The possible interactions of the important residues of PDHc-E1 with title compounds were studied by molecular docking, site-directed mutagenesis, and enzymatic assays. The results indicated that 11d had more potent inhibitory activity than that of 14d or I due to its 1,3,4-oxadiazole moiety with more binding position and stronger interaction with Lsy392 and His106 at active site of E. coli PDHc-E1.