73097-02-6Relevant articles and documents
RETINOID COMPOUND AND PHARMACEUTICAL COMPOSITION
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Paragraph 0041-0042, (2020/04/17)
PROBLEM TO BE SOLVED: To provide a novel retinoid compound that is low in teratogenicity, and a pharmaceutical composition containing said retinoid compound. SOLUTION: Provided are a retinoid compound which is a compound represented by the following formula (1) or a salt thereof, and a pharmaceutical composition containing said retinoid compound. In the formula, R1 represents a halogen atom, and R2 and R3 each independently represent a silyl group. SELECTED DRAWING: None COPYRIGHT: (C)2020,JPOandINPIT
Discovery of pyrido[3,4-g]quinazoline derivatives as CMGC family protein kinase inhibitors: Design, synthesis, inhibitory potency and X-ray co-crystal structure
Esvan, Yannick J.,Zeinyeh, Wael,Boibessot, Thibaut,Nauton, Lionel,Théry, Vincent,Knapp, Stefan,Chaikuad, Apirat,Loa?c, Nadège,Meijer, Laurent,Anizon, Fabrice,Giraud, Francis,Moreau, Pascale
, p. 170 - 177 (2016/05/09)
The design and synthesis of new pyrido[3,4-g]quinazoline derivatives is described as well as their protein kinase inhibitory potencies toward five CMGC family members (CDK5, CK1, GSK3, CLK1 and DYRK1A). The interest for this original tricyclic heteroaroma
Guanidino substituted isoindolones as novel glycoprotein IIb-IIIa receptor antagonists
Lal, Bansi,Gangopadhyay, Ashok K.,Jagtap,Tanpure, Rajendra,Rao,Gupte, Ravindra D.,Subbarayan,Asudani, Gope
, p. 1815 - 1832 (2008/09/18)
Design and synthesis of a novel potent glycoprotein IIb-IIIa (GP IIb-IIIa) receptor antagonist based on isoindolone skeleton has been described. This scaffold has been derived from earlier reported pseudopeptides. Synthesis by a novel route has been achieved. Few molecules show very potent in vitro activity. Further identification of probable additional hydrogen bond donor site has been described.