673486-70-9

Basic information

• Product Name: 3-Pyridazinecarboxylic acid, 1,4,5,6-tetrahydro-1-[(4-methoxyphenyl)methyl]-6-oxo-, methyl ester
• CAS NO: 673486-70-9
• Molecular Formula: C14H16N2O4
• Molecular Weight: 276.292
• Mol File: 673486-70-9.mol

Chemical Properties

• CAS DataBase Reference: 3-Pyridazinecarboxylic acid, 1,4,5,6-tetrahydro-1-[(4-methoxyphenyl)methyl]-6-oxo-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridazinecarboxylic acid, 1,4,5,6-tetrahydro-1-[(4-methoxyphenyl)methyl]-6-oxo-, methyl ester(673486-70-9)
• EPA Substance Registry System: 3-Pyridazinecarboxylic acid, 1,4,5,6-tetrahydro-1-[(4-methoxyphenyl)methyl]-6-oxo-, methyl ester(673486-70-9)

Safety Data

• Hazardous Substances Data: 673486-70-9(Hazardous Substances Data)

Upstream product

• 89532-94-5 methyl 6-oxo-1,4,5,6-tetrahydropyridazine-3-carboxylate 
• 824-94-2 p-methoxybenzyl chloride 
• 13192-04-6 dimethyl 2-ketoglutarate 

Downstream Products

• 690633-29-5 N-(2-Boc-aminoethyl)-N-{4-[1-(4-methoxybenzyl)-6-oxo-1,6-dihydropyridazin-3-yl]-but-3-enoyl} glycine methyl ester 
• 690633-28-4 E-4-[1-(4-methoxybenzyl)-6-oxo-1,6-dihydropyridazin-3-yl]-but-3-enoic acid 
• 673486-72-1 1-(4-methoxybenzyl)-6-oxo-1,6-dihydropyridazine-3-carbaldehyde 
• 673486-71-0 1-(4-methoxybenzyl)-6-oxo-1,4,5,6-tetrahydropyridazine-3-methanol 

Relevant articles and documents

A novel PNA-monomer for recognition of thymine in triple-helix structures

To expand the triplex recognition repertoire of Nucleic Acids, novel nucleobases that recognize thymine in a T-A base pair are still required. A novel conformationally constrained PNA-monomer (II) capable of binding T in a triplex motif was designed and s

Synthesis and evaluation of a conformationally constrained pyridazinone PNA-monomer for recognition of thymine in triple-helix structures

A novel conformationally constrained pyridazinone Eag-base PNA-monomer 2 capable of binding thymine in a triplex motif was designed and synthesised. A bis-PNA with the Eag-base incorporated in the Hoogsteen strand was hybridised with a complementary DNA. Thermal stability studies revealed an increase in Tm (4.3°C per mod.) compared to a no-base unit, but showed no improvement over a previously described unconstrained analogue (E, 1). Surprisingly, no significant difference was found in the thermodynamic parameters (ΔH°, ΔS° and ΔG°) for PNA-DNA triplex formation involving 2 or the unconstrained analogue 1.