67367-33-3 Usage
Uses
Used in Organic Synthesis:
4-Hydroxy-6-methylnicotinic acid is used as a building block in organic synthesis for the creation of various complex molecules. Its unique structure allows for the formation of new compounds with potential applications in different industries.
Used in Pharmaceutical Applications:
4-Hydroxy-6-methylnicotinic acid is used as a potential active pharmaceutical ingredient (API) for the development of new drugs. Its presence in biological systems suggests that it may have therapeutic properties, and further research could lead to its use in treating various medical conditions.
Used in Biochemical Research:
4-Hydroxy-6-methylnicotinic acid is used as a research tool in biochemical studies to understand its role in biological processes. This knowledge can contribute to the development of new therapeutic strategies and a better understanding of the underlying mechanisms of certain diseases.
Used in Plant and Animal Tissue Studies:
4-Hydroxy-6-methylnicotinic acid is used as a marker or indicator in studies of plant and animal tissues to investigate its distribution, metabolism, and potential interactions with other compounds. This can provide insights into the compound's biological functions and its potential applications in agriculture or medicine.
Check Digit Verification of cas no
The CAS Registry Mumber 67367-33-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,7,3,6 and 7 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 67367-33:
(7*6)+(6*7)+(5*3)+(4*6)+(3*7)+(2*3)+(1*3)=153
153 % 10 = 3
So 67367-33-3 is a valid CAS Registry Number.
InChI:InChI=1/C7H7NO3/c1-4-2-6(9)5(3-8-4)7(10)11/h2-3H,1H3,(H,8,9)(H,10,11)
67367-33-3Relevant academic research and scientific papers
A tautomeric ligand enables directed C-H hydroxylation with molecular oxygen
Li, Zhen,Wang, Zhen,Chekshin, Nikita,Qian, Shaoqun,Qiao, Jennifer X.,Cheng, Peter T.,Yeung, Kap-Sun,Ewing, William R.,Yu, Jin-Quan
, p. 1452 - 1457 (2021/06/30)
Hydroxylation of aryl carbon-hydrogen bonds with transition metal catalysts has proven challenging when oxygen is used as the oxidant. Here, we report a palladium complex bearing a bidentate pyridine/ pyridone ligand that efficiently catalyzes this reaction at ring positions adjacent to carboxylic acids. Infrared, x-ray, and computational analysis support a possible role of ligand tautomerization from monoanionic (L,X) to neutral (L,L) coordination in the catalytic cycle of aerobic carbon-hydrogen hydroxylation reaction. The conventional site selectivity dictated by heterocycles is overturned by this catalyst, thus allowing late-stage modification of compounds of pharmaceutical interest at previously inaccessible sites.
