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Usage

Uses

Used in Pharmaceutical Industry:
PYRAZINE-2,3-DICARBOXYLIC ACID MONOAMIDE is used as a chemical intermediate for the synthesis of various drugs and active pharmaceutical ingredients. Its unique structure and reactivity make it a valuable component in the development of new medications and therapeutic agents.
Used in Coordination Polymers and Metal-Organic Frameworks:
PYRAZINE-2,3-DICARBOXYLIC ACID MONOAMIDE is used as a building block in the preparation of coordination polymers and metal-organic frameworks. These materials have a wide range of applications in various industries, including catalysis, gas storage and separation, and sensing, due to their tunable structures and properties.

Upstream product

• 4744-50-7 2,3-pyrazinedicarboxylic anhydride 
• 13481-25-9 pyrazine-2,3-dicarbonitrile 
• 66505-29-1 3-cyanopyrazine-2-carboxamide 
• 6164-78-9 pyrazine-2,3-dicarboxamide 

Downstream Products

• 98-96-4 pyrazinamide 
• 89-01-0 2,3-dicarboxypyrazine 
• 70546-26-8 3-cyanopyrazine-2-carboxylic acid 
• 1260248-29-0 N-((3-bromophenyl)(3-cyanopyrazin-2-yl)methylene)-2-methylpropane-2-sulfinamide 
• 1260248-28-9 3-(3-bromobenzoyl)pyrazine-2-carbonitrile 
• 1260248-27-8 5-(3-bromophenyl)-5-(4-methoxy-3,5-dimethylphenyl)-5H-pyrrolo[3,4-b]pyrazin-7-amine 
• 1260248-26-7 N-((3-cyanopyrazin-2-yl)(4-methoxy-3,5-dimethylphenyl)methylene)-2-methylpropane-2-sulfinamide 
• 1260248-24-5 (S)-5-(4-methoxy-3,5-dimethylphenyl)-5-(3-(5-(prop-1-ynyl)pyridin-3-yl)phenyl)-5H-pyrrolo[3,4-b]pyrazin-7-amine 
• 1260248-25-6 3-(4-methoxy-3,5-dimethylbenzoyl)pyrazine-2-carbonitrile 
• 1260248-21-2 (S)-5-(4-methoxy-3,5-dimethylphenyl)-5-(3-(pyrazin-2-yl)phenyl)-5H-pyrrolo[3,4-b]pyrazin-7-amine 
• 1260248-06-3 5-(4-methoxy-3,5-dimethylphenyl)-5-(3-(pyrazin-2-yl)phenyl)-5H-pyrrolo[3,4-b]pyrazin-7-amine 
• 1260248-02-9 5-(4-methoxy-3,5-dimethylphenyl)-5-(3-(pyrimidin-5-yl)phenyl)-5H-pyrrolo[3,4-b]pyrazin-7-amine 
• 1260248-30-3 (R)-5-(3-bromophenyl)-5-(4-methoxy-3,5-dimethylphenyl)-5H-pyrrolo[3,4-b]pyrazin-7-amine 
• 1260248-31-4 5-(3-bromophenyl)-5-(4-methoxy-3,5-dimethylphenyl)-5H-pyrrolo[3,4-b]pyrazin-7-amine 

Relevant academic research and scientific papers

Nucleophically transformed N-heterocyclic nitriles trapped by cyanooxomolybdates(IV): Crystallographic and spectroscopic study

The reaction of K3Na[Mo(CN)4O2] ·6H2O with 2,3-dicyanopyrazine or 2-pyridinecarbonitrile in aqueous media results in isolation of two new compounds of formulae (PPh 4)2[Mo(CN)3O(pzac)]·2H2O (Hpzac = 3-carbamoyl-2-pyrazinecarboxylic acid) and (PPh4) 2[Mo(CN)3O(pynccn)]·3H2O·EtOH (Hpynccn = 2-pyridineiminocarbonitrile) respectively. X-ray single crystal structure measurements as well as physicochemical measurements confirm transformations of 2,3-dicyanopyrazine to 3-carbamoyl-2-pyrazinecarboxylic acid and 2-pyridinecarbonitrile to 2-pyridineiminocarbonitrile. All complexes are characterized by elemental analysis, IR and UV-Vis spectroscopy. Metal-assisted ligand transformations are studied spectrophotometrically in the pH range 8.5-11.5. Two different pathways of nitrile reactivity are shown and discussed.