67367-37-7

Basic information

• Product Name: PYRAZINE-2,3-DICARBOXYLIC ACID MONOAMIDE
• Synonyms: IFLAB-BB F2124-0962;3-AMINOCARBONYLPYRAZINE-2-CARBOXYLIC ACID;3-CARBAMOYLPYRAZINE-2-CARBOXYLIC ACID;AKOS BBS-00003097;PYRAZINE-2,3-DICARBOXYLIC ACID MONOAMIDE;Pyrazinedicarboxylicacidmonoamide;3-Aminocarbonyl-2-pyrazinecarboxylic acid;pyrazine-2,3-dicarboxylicacidmonoamide96+%
• CAS NO: 67367-37-7
• Molecular Formula: C₆H₅N₃O₃
• Molecular Weight: 167.12
• Product Categories: Pyrazinecarboxylic Acid & Derivatives;Pyrazines
• Mol File: 67367-37-7.mol
• Article Data: 1

Chemical Properties

• Melting Point: 156℃ (分解)
• Boiling Point: 464.4 °C at 760 mmHg
• Flash Point: 234.7 °C
• Appearance: /
• Density: 1.560±0.06 g/cm3 (20 ºC 760 Torr)
• CAS DataBase Reference: PYRAZINE-2,3-DICARBOXYLIC ACID MONOAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: PYRAZINE-2,3-DICARBOXYLIC ACID MONOAMIDE(67367-37-7)
• EPA Substance Registry System: PYRAZINE-2,3-DICARBOXYLIC ACID MONOAMIDE(67367-37-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 24/25-26
• Hazardous Substances Data: 67367-37-7(Hazardous Substances Data)

Usage

General Description

PYRAZINE-2,3-DICARBOXYLIC ACID MONOAMIDE, also known as 2,3-pyrazinedicarboxylic acid monoamide, is a chemical compound with the molecular formula C6H5N3O4. It is a monoamide derivative of 2,3-pyrazinedicarboxylic acid and is commonly used in the pharmaceutical industry as an intermediate for the synthesis of various drugs and active pharmaceutical ingredients. PYRAZINE-2,3-DICARBOXYLIC ACID MONOAMIDE is also used as a building block in the preparation of coordination polymers and metal-organic frameworks for various industrial applications. PYRAZINE-2,3-DICARBOXYLIC ACID MONOAMIDE is a white to off-white crystalline solid that is soluble in organic solvents and is stable under normal conditions of use and storage.

Upstream product

• 66505-29-1 3-cyanopyrazine-2-carboxamide 
• 13481-25-9 pyrazine-2,3-dicarbonitrile 
• 6164-78-9 pyrazine-2,3-dicarboxamide 
• 4744-50-7 2,3-pyrazinedicarboxylic anhydride 

Downstream Products

• 98-96-4 pyrazinamide 
• 74402-57-6 methyl 3-cyanopyrazine-2-carboxylate 
• 1260248-03-0 5-(4-methoxy-3,5-dimethylphenyl)-5-(3-(pyrimidin-5-yl)phenyl)-5H-pyrrolo[3,4-b]pyrazin-7-amine 
• 1260248-04-1 5-(4-methoxy-3,5-dimethylphenyl)-5-(3-(pyrimidin-5-yl)phenyl)-5H-pyrrolo[3,4-b]pyrazin-7-amine 
• 1260248-33-6 3-(3-fluoro-4-methoxybenzoyl)pyrazine-2-carbonitrile 
• 1260248-30-3 (R)-5-(3-bromophenyl)-5-(4-methoxy-3,5-dimethylphenyl)-5H-pyrrolo[3,4-b]pyrazin-7-amine 
• 1260248-31-4 5-(3-bromophenyl)-5-(4-methoxy-3,5-dimethylphenyl)-5H-pyrrolo[3,4-b]pyrazin-7-amine 
• 1260248-02-9 5-(4-methoxy-3,5-dimethylphenyl)-5-(3-(pyrimidin-5-yl)phenyl)-5H-pyrrolo[3,4-b]pyrazin-7-amine 
• 1260248-06-3 5-(4-methoxy-3,5-dimethylphenyl)-5-(3-(pyrazin-2-yl)phenyl)-5H-pyrrolo[3,4-b]pyrazin-7-amine 
• 1260248-21-2 (S)-5-(4-methoxy-3,5-dimethylphenyl)-5-(3-(pyrazin-2-yl)phenyl)-5H-pyrrolo[3,4-b]pyrazin-7-amine 
• 1260248-25-6 3-(4-methoxy-3,5-dimethylbenzoyl)pyrazine-2-carbonitrile 
• 1260248-24-5 (S)-5-(4-methoxy-3,5-dimethylphenyl)-5-(3-(5-(prop-1-ynyl)pyridin-3-yl)phenyl)-5H-pyrrolo[3,4-b]pyrazin-7-amine 
• 1260248-26-7 N-((3-cyanopyrazin-2-yl)(4-methoxy-3,5-dimethylphenyl)methylene)-2-methylpropane-2-sulfinamide 
• 1260248-27-8 5-(3-bromophenyl)-5-(4-methoxy-3,5-dimethylphenyl)-5H-pyrrolo[3,4-b]pyrazin-7-amine 

Relevant articles and documents

Nucleophically transformed N-heterocyclic nitriles trapped by cyanooxomolybdates(IV): Crystallographic and spectroscopic study

The reaction of K3Na[Mo(CN)4O2] ·6H2O with 2,3-dicyanopyrazine or 2-pyridinecarbonitrile in aqueous media results in isolation of two new compounds of formulae (PPh 4)2[Mo(CN)3O(pzac)]·2H2O (Hpzac = 3-carbamoyl-2-pyrazinecarboxylic acid) and (PPh4) 2[Mo(CN)3O(pynccn)]·3H2O·EtOH (Hpynccn = 2-pyridineiminocarbonitrile) respectively. X-ray single crystal structure measurements as well as physicochemical measurements confirm transformations of 2,3-dicyanopyrazine to 3-carbamoyl-2-pyrazinecarboxylic acid and 2-pyridinecarbonitrile to 2-pyridineiminocarbonitrile. All complexes are characterized by elemental analysis, IR and UV-Vis spectroscopy. Metal-assisted ligand transformations are studied spectrophotometrically in the pH range 8.5-11.5. Two different pathways of nitrile reactivity are shown and discussed.