67382-44-9Relevant academic research and scientific papers
Carbonylative addition of arylboronic acids to terminal alkynes: A new catalytic access to α,β-unsaturated ketones
Dheur, Julien,Sauthier, Mathieu,Castanet, Yves,Mortreux, Andre
, p. 2499 - 2506 (2008/09/19)
The carbonylative addition of arylboronic acids to terminal alkynes under mild conditions affords (E)-α,β-unsaturated ketones with good yields. The reaction was achieved with chloro(1,5-cyclooctadiene)rhodium(I) dimer or chlorodicarbonylrhodium(I) dimer a
Structure-activity studies of 5-substituted pyridopyrimidines as adenosine kinase inhibitors
Cowart, Marlon,Lee, Chih-Hung,Gfesser, Gregory A.,Bayburt, Erol K.,Bhagwat, Shripad S.,Stewart, Andrew O.,Yu, Haixia,Kohlhaas, Kathy L.,McGaraughty, Steve,Wismer, Carol T.,Mikusa, Joseph,Zhu, Chang,Alexander, Karen M.,Jarvis, Michael F.,Kowaluk, Elizabeth A.
, p. 83 - 86 (2007/10/03)
The synthesis and SAR of a novel series of non-nucleoside pyridopyrimidine inhibitors of the enzyme adenosine kinase (AK) are described. It was found that pyridopyrimidines with a broad range of medium and large non-polar substituents at the 5-position potently inhibited AK activity. A narrower range of analogues was capable of potently inhibiting adenosine phosphorylation in intact cells indicating an enhanced ability of these analogues to penetrate cell membranes. Potent AK inhibitors were found to effectively reduce nociception in animal models of thermal hyperalgesia and persistent pain. (C) 2000 Elsevier Science Ltd.
α,β-Unsaturated ketones and aldehydes and method of preparation
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, (2008/06/13)
α,β-Unsaturated ketones and aldehydes, together with a method of preparation thereof which comprises reacting aldehydes and cyclic and acyclic ketones possessing a methyl or methylene group α- to the carbonyl function with N,N-dialkylformamide dialkyl acetal to yield the corresponding enaminoketones and enaminoaldehydes, which enaminoketones and enaminoaldehydes are allowed to react with alkyllithium reagents to yield the corresponding nitrogen-free 2-alkylidene ketones and 2-alkylidene aldehydes.
