673855-17-9

Basic information

• Product Name: N-(3,5-dimethyl-1H-pyrazol-4-yl)-N'-phenylthiourea
• Synonyms: N-(3,5-dimethyl-1H-pyrazol-4-yl)-N'-phenylthiourea
• CAS NO: 673855-17-9
• Molecular Formula: C12H14N4S
• Molecular Weight: 246.33136
• Mol File: 673855-17-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(3,5-dimethyl-1H-pyrazol-4-yl)-N'-phenylthiourea(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3,5-dimethyl-1H-pyrazol-4-yl)-N'-phenylthiourea(673855-17-9)
• EPA Substance Registry System: N-(3,5-dimethyl-1H-pyrazol-4-yl)-N'-phenylthiourea(673855-17-9)

Safety Data

• Hazardous Substances Data: 673855-17-9(Hazardous Substances Data)

Upstream product

• 5272-86-6 4-amino-3,5-dimethyl-1H-pyrazole 
• 103-72-0 phenyl isothiocyanate 
• 6134-57-2 pentane-2,3,4-trione 3-phenylhydrazone 
• 3656-05-1 3,5-dimethyl-4-(phenyldiazenyl)-1H-pyrazole 
• 123-54-6 acetylacetone 

Relevant articles and documents

Synthesis and biological evaluation of new N-substituted-N′-(3,5-di/ 1,3,5-trimethylpyrazole-4-yl)thiourea/urea derivatives

Several thiourea and urea derivatives were prepared by the reaction of 4-aminopyrazoles with substituted isothiocyanates or isocyanates. The novel compounds were tested anticonvulsant activity using by pentylenetetrazole- induced seizure (PTZ) and maximal electroshock seizure (MES) tests. Among the tested compounds, thiourea derivatives of 4b were afforded 90 and 100% protection in PTZ and MES tests at 50 mg/kg, respectively. Urea derivatives of 5a and 5b were afforded 82 and 100% protection both at 25 and 50 mg/kg. Also synthesized compounds were screened for antituberculosis activity against Mycobacterium tuberculosis H37Rv at 6.25 μg/mL concentration but they were not found active at these concentration. In addition, some selected compounds were evaluated for in vitro anti-HIV activity and they were all negative.