673855-68-0Relevant academic research and scientific papers
Evaluation of the tubulin-bound paclitaxel conformation: Synthesis, biology, and SAR studies of C-4 to C-3′ bridged paclitaxel analogues
Ganesh, Thota,Yang, Chao,Norris, Andrew,Glass, Tom,Bane, Susan,Ravindra, Rudravajhala,Banerjee, Abhijit,Metaferia, Belhu,Thomas, Shala L.,Giannakakou, Paraskevi,Alcaraz, Ana A.,Lakdawala, Ami S.,Snyder, James P.,Kingston, David G. I.
, p. 713 - 725 (2007/10/03)
The important anticancer drug paclitaxel binds to the β-subunit of the ββ-tubulin dimer in the microtubule in a stoichiometric ratio, promoting microtubule polymerization and stability. The conformation of microtubule-bound drug has been the subject of in
CONFORMATIONALLY CONSTRAINED PACLITAXEL ANALOGS AND THEIR USE AS ANTICANCER AND ANTI-ALZHEIMERS AGENTS
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Page/Page column Fig. 3; 5, (2010/02/13)
Constrained paclitaxel derivatives include a bridge extending from the C-3’ phenyl to either the C4 or -3 positions. Many of the constrained paclitaxel derivatives provide activity comparable or superior to the natural product paclitaxel.
Lipase-catalyzed resolution of 4-aryl-substituted β-lactams: Effect of substitution on the 4-aryl ring
Carr, Jason A.,Al-Azemi, Talal F.,Long, Timothy E.,Shim, Jeung-Yeop,Coates, Cristina M.,Turos, Edward,Bisht, Kirpal S.
, p. 9147 - 9160 (2007/10/03)
Pseudomonas cepacia lipase (PS-30) was used in hydrolytic resolution of 3-acetoxy-4-aryl-substituted azetidin-2-ones (>97% ee). Twenty-three β-lactam substrates with varied substituents at the C-4 center of the ring were synthesized and subjected to lipas
