6742-32-1

Usage

Derived from benzo[7]annulene

A polycyclic aromatic hydrocarbon 2-(5-Oxo-6,7,8,9-Tetrahydro-5H-Benzo[7]Annulen-6-Yl)Acetic Acid is a synthetic derivative of a naturally occurring hydrocarbon with a ring structure.

Classification

Carboxylic acid 2-(5-Oxo-6,7,8,9-Tetrahydro-5H-Benzo[7]Annulen-6-Yl)Acetic Acid contains a carboxyl functional group (-COOH).

Structural features

Gamma-lactone and phenyl group The compound has a gamma-lactone ring (a lactone with a five-membered ring) and a phenyl group (a carbon ring with delocalized electrons).

Uses

Organic synthesis and chemical research 2-(5-Oxo-6,7,8,9-Tetrahydro-5H-Benzo[7]Annulen-6-Yl)Acetic Acid is commonly used as a building block or reagent in the synthesis of other organic compounds and for studying chemical reactions and processes.

Potential applications

Pharmaceuticals or materials science 2-(5-Oxo-6,7,8,9-Tetrahydro-5H-Benzo[7]Annulen-6-Yl)Acetic Acid may have potential uses in the development of new drugs or materials due to its unique structure and properties.

Unique structure and properties

Interesting target for further study and development The compound's structure and properties make it a promising candidate for further research and development in various fields.

InChI:InChI=1/C13H14O3/c14-12(15)8-10-6-3-5-9-4-1-2-7-11(9)13(10)16/h1-2,4,7,10H,3,5-6,8H2,(H,14,15)

Upstream product

• 74821-55-9 methyl 5-oxo-6,7,8,9-tetrahydro-5H-benzo[7]annulene-6-carboxylate 
• 105-36-2 ethyl bromoacetate 
• 855385-26-1 5-oxo-6,7,8,9-tetrahydro-5H-benzocycloheptene-6-carboxylic acid benzyl ester 
• 130922-07-5 5-oxobenzocycloheptane-Δ^6,α-acetic acid 
• 25742-81-8 ethyl 2-(5-oxo-6,7,8,9-tetrahydro-5H-benzo[7]annulene-6-yl)acetate 
• 7248-68-2 10-oxa-3,4-benzobicyclo<5.3.0>deca-1(7)-ene-8,9-dione 
• 826-73-3 1-Benzosuberone 

Downstream Products

• 157131-45-8 6-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-2-oxo-ethyl}-6,7,8,9-tetrahydro-benzocyclohepten-5-one 
• 1026933-63-0 C₂₉H₃₆FNO₄ 
• 1027594-19-9 C₂₉H₃₄FNO₅ 
• 25742-87-4 2,4,4a,5,6,7-hexahydro-3H-benzo<6,7>cyclohepta<1,2-c>pyridazin-3-one 
• 25823-52-3 2,5,6,7-tetrahydro-3H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-one 
• 25823-53-4 3-chloro-2,5,6,7-tetrahydro-3H-benzo[6,7]cyclohepta[1,2-c]pyridazine 
• 802598-74-9 3-hydrazino-6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazine 

Relevant academic research and scientific papers

Structure-based discovery of receptor tyrosine kinase AXL degraders with excellent anti-tumor activity by selectively degrading AXL and inducing methuosis

The receptor tyrosine kinase (RTK) anexelekto (AXL) is mutated and/or overexpressed in various malignancies, and plays a central role in tumor development and acquired drug resistance. Although highly selective inhibitors have been developed in recent years, direct inhibition of AXL may block its ubiquitination, eventually leading to surface accumulation of the protein. Herein, we designed and synthesized a series of AXL degraders with high selectivity and without compensatory increase of AXL. In particular, compounds 20 and 22 showed significant AXL degradation capacity, which inhibited the proliferation and migration of cancer cells in vitro. In addition, these compounds induced the formation of cytoplasmic vacuoles and triggered methuosis, a new type of non-apoptotic cell death, by stimulating excessive production of macropinosomes. Vacuole formation was mediated via H-Ras activation, and was attenuated upon inhibition of its downstream regulatory factor Rac1. Furthermore, compound 20 inhibited the growth of tumor cell xenografts in vivo, and prolonged the survival of the tumor-bearing mice.

AXL INHIBITORS FOR USE IN COMBINATION THERAPY FOR PREVENTING, TREATING OR MANAGING METASTATIC CANCER

This invention is directed to methods of preventing, treating or managing cancer, preferably metastatic cancer, in a patient. The methods comprise administering an effective amount of an Axl inhibitor in combination with the administration of an effective

Multiple Absolute Stereocontrol in Cascade Lactone Formation via Dynamic Kinetic Resolution Driven by the Asymmetric Transfer Hydrogenation of Keto Acids with Oxo-Tethered Ruthenium Catalysts

A straightforward asymmetric construction of chiral fused γ- and δ-lactones containing multiple contiguous stereocenters was successfully developed by either (1) the dynamic kinetic resolution-asymmetric transfer hydrogenation (DKR-ATH) reaction using oxo

Bemcentinib: Rec INN

Increased expression of Axl has been reported in various cancers including colon, esophageal, thyroid, breast, lung, liver and astrocytoma-glioblastoma. Cancer resistance to tyrosine kinase inhibitors and other chemotherapeutics has been correlated with a

POLYCYCLIC HETEROARYL SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS

Polycyclic heteroaryl substituted triazoles and pharmaceutical compositions containing the compounds are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the compounds in treating diseases

POLYCYCLIC ARYL SUBSTITUTED TRIAZOLES AND POLYCYCLIC HETEROARYL SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS

Polycyclic aryl and polycyclic heteroaryl substituted triazoles and pharmaceutical compositions containing the compounds are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the compounds in treating diseases or conditions associated with Axl catalytic activity are also disclosed.

BICYCLIC ARYL AND BICYCLIC HETEROARYL SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS

Bicyclic aryl substituted triazoles or heteroaryl substituted triazoles and pharmaceutical compositions containing the compounds are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the com

POLYCYCLIC HETEROARYL SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS

Polycyclic heteroaryl substituted triazoles and pharmaceutical compositions containing the compounds are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the compounds in treating diseases

Synthesis and atypical antipsychotic profile of some 2-(2- piperidinoethyl)benzocycloalkanones as analogues of butyrophenone

Four new 2-(2-piperidinoethyl)benzocycloalkanone derivatives, 20-23, were prepared and evaluated as potential antipsychotic agents in receptor binding assays for dopamine (DA) and 5-HT(2A) receptors and in functional and behavioral screens. Their affiniti