67421-74-3

Basic information

• Product Name: Benzeneacetic acid, a-(formylamino)-
• CAS NO: 67421-74-3
• Molecular Formula: C9H9NO3
• Molecular Weight: 179.175
• Mol File: 67421-74-3.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzeneacetic acid, a-(formylamino)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetic acid, a-(formylamino)-(67421-74-3)
• EPA Substance Registry System: Benzeneacetic acid, a-(formylamino)-(67421-74-3)

Safety Data

• Hazardous Substances Data: 67421-74-3(Hazardous Substances Data)

Upstream product

• 64-18-6 formic acid 
• 611-73-4 Benzoylformic acid 
• 875-74-1 D-α-phenylglycine 
• 77287-34-4 formamide 
• 2835-06-5 phenylglycin 
• 108-24-7 acetic anhydride 

Downstream Products

• 27594-65-6 N-methyl-2-amino-2-phenylethanol 
• 875-74-1 D-α-phenylglycine 
• 69-91-0 L-α-phenylglycine 
• 336105-88-5 2-isocyano-1-morpholin-4-yl-2-phenylethanone 
• 2935-35-5 (S)-2-phenylglycine 
• 1256778-11-6 N-[2-(3,4-dimethoxy-phenyl)-ethyl]-2-formylamino-2-phenyl-acetamide 

Relevant articles and documents

Divergent Synthesis of Enantioenriched β-Functional Amines via Desymmetrization of meso-Aziridines with Isocyanides

A highly enantioselective ring-opening desymmetrization of meso-aziridines with isocyanides was achieved in the presence of a chiral N,N′-dioxide/Mg(OTf)2 complex. The in situ generated chiral 1,4-zwitterionic intermediates were successfully trapped by intramolecular oxygen- and carbon-based nucleophiles or exogenous H2O and TMSN3, enabling a collective synthesis of various chiral vicinal amino-oxazoles, spiroindolines, β-amino amides, and tetrazole derivative in moderate to high yields with excellent enantioselectivities.

(DIHYDRO) IMIDAZOISO (5, 1-A) QUINOLINES AS FSH RECEPTOR AGONISTS FOR THE TREATMENT OF FERTILITY DISORDERS

The invention relates to imidazoiso[5,1-a]quinoline and 5,6-dihydro-imidazoiso[5,1-a]quinoline derivatives according to general Formula (1) or a pharmaceutically acceptable salt thereof. The compounds can be used for the treatment of infertility.

A New Approach to Asymmetric Synthesis of Polycycles on the Basis of o-Quinodimethane Generation

The fluoride anion induced 1,4-elimination of 2-phenyl>-3,3-dimethyloxazolidinium salts generates (E,E)-α-alkyl-α'--o-quinodimethane intermediates, which are trapped stereoselectively with dienophiles to give polycycles.Intramolecular cyclization of 2-phenyl>-3,3-dimethyl-4-(R)-methyl-5(R)-phenyloxazolidinium triflate at 0 deg C produces a 3:1 diastereoisomeric mixture of 6--trans-octahydrophenanthrene, which is converted by hydrogenolysis on Pd/C to trans-octahydrophenanthrene with D +46.6 deg (50percent ee).Similarly, intramolecular cyclization of 2-phenyl>-3,3-dimethyl-4(S)-methoxymethyl-5(S)-phenyloxazolidinium triflate produces, after hydrogenolysis on Pd/C, trans-octahydrophenanthrene with D -51.1 deg (55percent ee).The enantioselection in the cycloaddition with o-quinodimethane intermediate may be accounted for on the basis of ?-stacking interaction in the Diels-Alder transition state.