67421-74-3Relevant academic research and scientific papers
Divergent Synthesis of Enantioenriched β-Functional Amines via Desymmetrization of meso-Aziridines with Isocyanides
Li, Xiangqiang,Xiong, Qian,Guan, Mingming,Dong, Shunxi,Liu, Xiaohua,Feng, Xiaoming
supporting information, p. 6096 - 6101 (2019/08/20)
A highly enantioselective ring-opening desymmetrization of meso-aziridines with isocyanides was achieved in the presence of a chiral N,N′-dioxide/Mg(OTf)2 complex. The in situ generated chiral 1,4-zwitterionic intermediates were successfully trapped by intramolecular oxygen- and carbon-based nucleophiles or exogenous H2O and TMSN3, enabling a collective synthesis of various chiral vicinal amino-oxazoles, spiroindolines, β-amino amides, and tetrazole derivative in moderate to high yields with excellent enantioselectivities.
A convenient procedure for N-formylation of amines
Joseph, Sony,Das, Prasenjit,Srivastava, Bindu,Nizar, Hashim,Prasad, Mohan
, p. 929 - 931 (2013/02/25)
A simple and convenient method for the N-formylation of primary and secondary amines including amino acids has been developed utilizing formamide and sodium methoxide in moderate to excellent yield. This reagent is also utilized for one pot conversion of compounds having amino esters to N-formyl amides.
(DIHYDRO) IMIDAZOISO (5, 1-A) QUINOLINES AS FSH RECEPTOR AGONISTS FOR THE TREATMENT OF FERTILITY DISORDERS
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Page/Page column 97, (2010/12/26)
The invention relates to imidazoiso[5,1-a]quinoline and 5,6-dihydro-imidazoiso[5,1-a]quinoline derivatives according to general Formula (1) or a pharmaceutically acceptable salt thereof. The compounds can be used for the treatment of infertility.
(DIHYDRO)IMIDAZOISO[5,1-A]QUINOLINES
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Page/Page column 52; 53, (2010/12/31)
The invention relates to imidazoiso[5,1-a]quinoline and 5,6-dihydro-imidazoiso[5,1-a]quinoline derivatives according to general Formula I or a pharmaceutically acceptable salt thereof. The compounds can be used for the treatment of infertility.
A New Approach to Asymmetric Synthesis of Polycycles on the Basis of o-Quinodimethane Generation
Ito, Yoshihiko,Amino, Yusuke,Nakatsuka, Masashi,Saegusa, Takeo
, p. 1586 - 1590 (2007/10/02)
The fluoride anion induced 1,4-elimination of 2-phenyl>-3,3-dimethyloxazolidinium salts generates (E,E)-α-alkyl-α'--o-quinodimethane intermediates, which are trapped stereoselectively with dienophiles to give polycycles.Intramolecular cyclization of 2-phenyl>-3,3-dimethyl-4-(R)-methyl-5(R)-phenyloxazolidinium triflate at 0 deg C produces a 3:1 diastereoisomeric mixture of 6--trans-octahydrophenanthrene, which is converted by hydrogenolysis on Pd/C to trans-octahydrophenanthrene with D +46.6 deg (50percent ee).Similarly, intramolecular cyclization of 2-phenyl>-3,3-dimethyl-4(S)-methoxymethyl-5(S)-phenyloxazolidinium triflate produces, after hydrogenolysis on Pd/C, trans-octahydrophenanthrene with D -51.1 deg (55percent ee).The enantioselection in the cycloaddition with o-quinodimethane intermediate may be accounted for on the basis of ?-stacking interaction in the Diels-Alder transition state.
Autorecycling System for the Synthesis of α-Amino-acids by the Reductive Amination of α-Keto-acids catalysed by 1,5-Dihydro-5-deazaflavin
Yoneda, Fumio,Kuroda, Kazunori
, p. 927 - 929 (2007/10/02)
An effective autorecycling system for the biomimetic synthesis of α-amino-acids by the reductive amination of α-keto-acids has been achieved for the first time using 10-aryl-5-deazaflavin, ammonium formate, and formic acid; each mole of the 5-deazaflavin catalyses the reduction, by formic acid, of up to 20 moles of the α-imino-acids formed in situ from the α-keto-acids and ammonium formate.
3-Heterothio derivatives of (formylamino)acetylamino-7-alpha-methoxy cephalosporins
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, (2008/06/13)
3-Heterothio(formylamino)acetylamino cephalosporin derivatives of the general formula STR1 wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, tri(lower alkyl)silyl, trihaloethyl, a salt forming ion or the group STR2 R1 is hydrogen, lower a
