67445-86-7

Usage

Uses

Used in Pharmaceutical Industry:
2-Bromo-N-[4-chloro-2-(4-hydroxybenzoyl)phenyl]acetamide is used as an intermediate in the preparation of Diazepam (D416855) for its anxiolytic, muscle relaxant, and anticonvulsant effects. 2-BroMo-N-[4-chloro-2-(4-hydroxybenzoyl)phenyl]acetaMide plays a crucial role in the development of medications that help alleviate anxiety, muscle tension, and seizure disorders.

Upstream product

• 784-41-8 2-amino-5-chloro-4'-hydroxy-benzophenone 
• 598-21-0 2-Bromoacetyl bromide 

Downstream Products

• 17270-12-1 4'-hydroxy-N-desmethyldiazepam 

Relevant academic research and scientific papers

Immunoassay for N-desmethyldiazepam

Highly specific antibodies to N-desmethyldiazepam are obtained by using as an immunogen 4'-hydrazinocarbonylmethoxy-N-desmethyldiazepam coupled to an immunogenic carrier material such as bovine serum albumin. These antibodies can be employed in immunoassa

Quinazolines and 1,4-benzodiazepines. LXXXIX: Haptens useful in benzodiazepine immunoassay development

The syntheses of some 1,4-benzodiazepines potentially useful as haptens are reported. These compounds are related to chlordiazepoxide, diazepam, nitrazepam, clonazepam, and some of their metabolites. The chemistry reported here is intended to support specific immunoassay development for these drugs.

Benzodiazepine radioimmunoassay using I125-label

An improved radioimmunoassay for benzodiazepines such as diazepam, chlordiazepoxide, oxazepam, demoxepam and metabolites thereof is disclosed. Such immunoassay employs novel 125 I-labelled 4'-hydroxy derivatives of these compounds as tracer.