784-41-8

Usage

Preparation

Preparation by cleavage of 5-chloro-3-(phydroxyphenyl)- 2,1-benzisoxazole (other name: 5-chloro-3-(p-hydroxy-phenyl)anthranil) (SM), ? by heating at reflux with aluminium iodide for 50 min (87%); ? by reaction with concentrated hydrochloric acid and an excess of tin in boiling ethanol or acetic acid. SM (m.p. 241°) was prepared by condensation of o-nitrobenzaldehyde with phenol in the presence of hydrogen chloride or phosphorous oxychloride in cold acetic acid; ? by hydrogenation in the presence of 10% Pd/C in ethyl acetate between 40° and 60° at a pressure of 3 atmospheres (quantitative yield).

Upstream product

• 728-22-3 3-(4-methoxybenzene)-5-chloro-2,1-benzoisoxazole 
• 121998-46-7 1-acetoxy-4-(5-chloro-benzo[c]isoxazol-3-yl)-benzene 
• 7497-59-8 (2-amino-5-chlorophenyl)(4-methoxyphenyl)methanone 
• 7647-01-0 hydrogenchloride 
• 64-17-5 ethanol 
• 67445-85-6 4-(5-chloro-benzo[c]isoxazol-3-yl)-phenol 
• 64-19-7 acetic acid 
• 7033-50-3 6-chloro-2-methyl-4H-benzo[d][1,3]oxazin-4-one 
• 271-58-9 anthranil 
• 38824-11-2 (2-aminophenyl)-(3-methoxyphenyl)methanone 
• 223247-80-1 (2-Amino-4-chlorophenyl)-(3-methoxyphenyl)-methanone 
• 635-21-2 5-chloroanthranilic acid 
• 34999-44-5 5-Chlor-2--4'-methoxy-benzophenon 

Downstream Products

• 857628-43-4 4-[1-(2-amino-5-chloro-phenyl)-vinyl]-phenol 
• 67445-86-7 2-bromo-4'-chloro-2'-(4-hydroxybenzoyl)acetanilide 
• 270903-84-9 2,5-dichloro-4'-hydroxy-benzophenone 
• 61002-52-6 3-chlorophenyl 4-hydroxyphenyl ketone 
• 136623-20-6 C₁₄H₁₄ClN₅O*2ClH 

Relevant academic research and scientific papers

Water promoted iodotrimethyl silane reactions: Reductive cleavage of isoxazolidines and 2,1-benzisoxazoles to γ-amino alcohols and o-aminobenzophenones

Water promoted iodotrimethyl silane [ITMS] reductively cleaved isoxazolidines and 2,1-benzisoxazoles to γ-amino alcohols and o-aminobenzophenones respectively at shorter times and in higher yields at room temperature.

Inhibitors of protein tyrosine kinases

Disclosed herein are small molecule, non-peptidyl inhibitors of protein tyrosine kinases, and methods for their use. The instant inhibitors are based on a 1,4-benzodiazepin-2-one nucleus. Methods are provided for inhibition of specific protein tyrosine kinases, for example pp60c-src. Methods are further provided for the use of these inhibitors in situations where the inhibition of a protein tyrosine kinase is indicated, for example, in the treatment of certain diseases in mammals, including humans.

A convenient method for the production of ortho-amino and N-alkylaminobenzophenones

ortho-Amino and N-alkylaminobenzophenones 3 have been prepared in good yields by the reductive cleavage of 2,1-benzisoxazole and its salts with Zn-AlCl3*6H2O/THF system.

A CONVENIENT SYNTHESIS OF 2-AMINOBENZOPHENONES USING IODOTRIMETHYLSILANE.

Iodotrimethylsilane reduces 3-aryl-2,1-benzisoxazole to o-amino-benzophenones.

Immunoassay for N-desmethyldiazepam

Highly specific antibodies to N-desmethyldiazepam are obtained by using as an immunogen 4'-hydrazinocarbonylmethoxy-N-desmethyldiazepam coupled to an immunogenic carrier material such as bovine serum albumin. These antibodies can be employed in immunoassa

Quinazolines and 1,4-benzodiazepines. LXXXIX: Haptens useful in benzodiazepine immunoassay development

The syntheses of some 1,4-benzodiazepines potentially useful as haptens are reported. These compounds are related to chlordiazepoxide, diazepam, nitrazepam, clonazepam, and some of their metabolites. The chemistry reported here is intended to support specific immunoassay development for these drugs.

Benzodiazepine radioimmunoassay using I125-label

An improved radioimmunoassay for benzodiazepines such as diazepam, chlordiazepoxide, oxazepam, demoxepam and metabolites thereof is disclosed. Such immunoassay employs novel 125 I-labelled 4'-hydroxy derivatives of these compounds as tracer.