784-41-8

Basic information

• Product Name: 2-AMino-5-chloro-4'-hydroxybenzophenone
• Synonyms: 2-AMino-5-chloro-4'-hydroxybenzophenone
• CAS NO: 784-41-8
• Molecular Formula: C₁₃H₁₀ClNO₂
• Molecular Weight: 247.677
• Mol File: 784-41-8.mol
• Article Data: 8

Chemical Properties

• Melting Point: 174°C
• Appearance: /
• CAS DataBase Reference: 2-AMino-5-chloro-4'-hydroxybenzophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMino-5-chloro-4'-hydroxybenzophenone(784-41-8)
• EPA Substance Registry System: 2-AMino-5-chloro-4'-hydroxybenzophenone(784-41-8)

Safety Data

• Hazardous Substances Data: 784-41-8(Hazardous Substances Data)

Usage

Preparation

Preparation by cleavage of 5-chloro-3-(phydroxyphenyl)- 2,1-benzisoxazole (other name: 5-chloro-3-(p-hydroxy-phenyl)anthranil) (SM), ? by heating at reflux with aluminium iodide for 50 min (87%); ? by reaction with concentrated hydrochloric acid and an excess of tin in boiling ethanol or acetic acid. SM (m.p. 241°) was prepared by condensation of o-nitrobenzaldehyde with phenol in the presence of hydrogen chloride or phosphorous oxychloride in cold acetic acid; ? by hydrogenation in the presence of 10% Pd/C in ethyl acetate between 40° and 60° at a pressure of 3 atmospheres (quantitative yield).

Upstream product

• 728-22-3 3-(4-methoxybenzene)-5-chloro-2,1-benzoisoxazole 
• 7647-01-0 hydrogenchloride 
• 64-17-5 ethanol 
• 67445-85-6 4-(5-chloro-benzo[c]isoxazol-3-yl)-phenol 
• 64-19-7 acetic acid 
• 635-21-2 5-chloroanthranilic acid 
• 38824-11-2 (2-aminophenyl)-(3-methoxyphenyl)methanone 
• 223247-80-1 (2-Amino-4-chlorophenyl)-(3-methoxyphenyl)-methanone 
• 271-58-9 anthranil 
• 34999-44-5 5-Chlor-2--4'-methoxy-benzophenon 
• 7033-50-3 6-chloro-2-methyl-4H-benzo[d][1,3]oxazin-4-one 
• 7497-59-8 (2-amino-5-chlorophenyl)(4-methoxyphenyl)methanone 
• 121998-46-7 1-acetoxy-4-(5-chloro-benzo[c]isoxazol-3-yl)-benzene 

Downstream Products

• 61002-52-6 3-chlorophenyl 4-hydroxyphenyl ketone 
• 857628-43-4 4-[1-(2-amino-5-chloro-phenyl)-vinyl]-phenol 
• 270903-84-9 2,5-dichloro-4'-hydroxy-benzophenone 
• 67445-86-7 2-bromo-4'-chloro-2'-(4-hydroxybenzoyl)acetanilide 
• 136623-20-6 C₁₄H₁₄ClN₅O*2ClH 

Relevant articles and documents

Water promoted iodotrimethyl silane reactions: Reductive cleavage of isoxazolidines and 2,1-benzisoxazoles to γ-amino alcohols and o-aminobenzophenones

Water promoted iodotrimethyl silane [ITMS] reductively cleaved isoxazolidines and 2,1-benzisoxazoles to γ-amino alcohols and o-aminobenzophenones respectively at shorter times and in higher yields at room temperature.

A convenient method for the production of ortho-amino and N-alkylaminobenzophenones

ortho-Amino and N-alkylaminobenzophenones 3 have been prepared in good yields by the reductive cleavage of 2,1-benzisoxazole and its salts with Zn-AlCl3*6H2O/THF system.

Immunoassay for N-desmethyldiazepam

Highly specific antibodies to N-desmethyldiazepam are obtained by using as an immunogen 4'-hydrazinocarbonylmethoxy-N-desmethyldiazepam coupled to an immunogenic carrier material such as bovine serum albumin. These antibodies can be employed in immunoassa