67451-42-7Relevant academic research and scientific papers
Semisynthetic cephalosporins. Synthesis and structure-activity relationships of 7-(1-pyrryl)- and 7-(1-indolyl)acetamidocephalosporin derivatives
Nudelman,Karoly,Braun,Boehme,Erickson
, p. 962 - 964 (1978)
A series of 1-pyrrole- and 1-indoleacetamido derivatives of 3-heteroaryl-substituted cephalosporins was prepared. The most active compound in the series was 7[[2-(1-pyrryl)acetyl]amino]-3-[[(1- methyltetrazol-5-yl)thio]-methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0] oct-2-ene-2-carboxylic acid, which showed comparable potency in vitro and in vivo to that of cefazolin, and, in addition, was more potent than cefazolin against Enterobacter sp. and Providencia stuartii.
New Melanoidin-like Maillard Polymers from 2-Deoxypentoses
Tressl, Roland,Wondark, Georg T.,Krueger, Ralph-Peter,Rewicki, Dieter
, p. 104 - 110 (1998)
In the 2-deoxy-D-ribose/methyl 4-aminobutyrate Maillard system a trapped N-substituted 2-(hy-droxymethyl)pyrrole is one of the major products. However, nontrapped representatives of this type of compound were hitherto not found in other Maillard model systems, indicating their extraordinary reactivity. Model experiments with 2-deoxy-D-ribose/methylamine enabled the detection of N-methyl-2-(hydroxymethyl)pyrrole (1) and some derived linear oligomers (2, 3) as minor components. Consequently, 1 was synthesized and its oligomerization studied under very mild acidic conditions. The deformylated dimeric bis(N-methyl-2-pyrrolyl)methane (2) and trimeric N-methyl-2,5-bis(N-methyl-2-pyrrolylmethyl)pyrrole (3) were characterized by GC/MS and NMR. Higher regular oligomers up to 6 N-methyl-2-pyrrolylmethyl units as well as corresponding dehydrooligomers up to 12 units were identified by MALDI-TOF-MS. A complementary experiment starting with N-methyl-2-hydroxy[13C]methylpyrrole [13CH2OH]-1) confirmed the structure and the oligomerization pathway. The possible significance of this type of model oligomer for the melanoidin formation in Maillard reactions is discussed. The antioxidative activity of the isolated dimer and trimer was tested in Fe(III)-thiocyanate and DPPH assays.
Azacycloalkanes: XXXIX. New Syntheses of 1H-Pyrrole-1-carboxylic acid and 1,2-dihydropyrrolo-[1,2-a]pyrazin-3(4H)-one derivatives
Mokrov,Likhosherstov,Troitskaya,Gudasheva
experimental part, p. 1829 - 1833 (2010/05/19)
New procedures have been developed for the synthesis of α-(2-formyl-1H-pyrrol-1-yl)-substituted carboxylic acids, α-(2-R-aminomethyl-1H-pyrrol-1-yl)-substituted carboxylic acids, and 1,2-dihydropyrrolo-[1,2-a]pyrazin-3(4H)-ones on the basis of furfurol and α-amino acids.
An efficient synthesis of 3-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-1- carboxamides using novel modification of Ugi condensation
Ilyn, Alexey P.,Kuzovkova, Julia A.,Shkirando, Alexandre M.,Ivachtchenko, Alexandre V.
, p. 523 - 526 (2007/10/03)
We present a convenient synthesis of novel 3-oxo-1,2,3,4- tetrahydropyrrolo[1,2-a]pyrazine-1-carboxamides using a modification of four-component Ugi condensation. According to this method, (2-formyl-1H-pyrrol- 1-yl)acetic acid is used as a bifunctional co
Improved functionalized resin for chemical synthesis
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, (2008/06/13)
A support functionalized by an indole or pyrrole aldehyde is useful for the solid phase synthesis of amide type compounds.
Synthesis of 1,2-Disubstituted Pyrroles: A Cis Peptide Bond Surrogate
Abell, Andrew D.,Hoult, Deborah A.,Jamieson, Emily J.
, p. 5831 - 5832 (2007/10/02)
1,2-Disubstituted pyrroles have been synthesized as surrogates of a Gly-X dipeptide bond; Key Words: Cis peptide bond surrogate; Dipeptide; Glycine; 1,2-Disubstituted pyrroles
Cephalosporin derivatives
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, (2008/06/13)
New cephalosporin derivatives containing a formyl substituted pyrrole group and the processes for preparing same are described.
