67453-81-0

Basic information

• Product Name: N-(4-BROMO-PHENYL)-GUANIDINE
• Synonyms: N-(4-BROMO-PHENYL)-GUANIDINE;1-(4-broMophenyl)guanidine;(4-bromophenyl)guanidine;2-(4-bromophenyl)guanidine
• CAS NO: 67453-81-0
• Molecular Formula: C₇H₈BrN₃
• Molecular Weight: 214.07
• Mol File: 67453-81-0.mol
• Article Data: 3

Chemical Properties

• Melting Point: >300 °C (decomp)
• Boiling Point: 284.4±42.0 °C(Predicted)
• Appearance: /
• Density: 1.67±0.1 g/cm3(Predicted)
• PKA: 10.67±0.10(Predicted)
• CAS DataBase Reference: N-(4-BROMO-PHENYL)-GUANIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-BROMO-PHENYL)-GUANIDINE(67453-81-0)
• EPA Substance Registry System: N-(4-BROMO-PHENYL)-GUANIDINE(67453-81-0)

Safety Data

• Hazardous Substances Data: 67453-81-0(Hazardous Substances Data)

Usage

Description

N-(4-BROMO-PHENYL)-GUANIDINE is an organic compound that features a guanidine functional group attached to a 4-bromo-phenyl moiety. This chemical structure endows it with unique properties that make it a versatile building block in organic synthesis and a potential candidate for pharmaceutical applications.

Uses

Used in Pharmaceutical Industry:
N-(4-BROMO-PHENYL)-GUANIDINE is used as a synthetic intermediate for the development of molecules targeting urokinase inhibition. Urokinase is an enzyme involved in various physiological processes, and its inhibition can be therapeutically beneficial in treating conditions related to abnormal cell proliferation and metastasis in cancer.
Used in Organic Synthesis:
In the field of organic synthesis, N-(4-BROMO-PHENYL)-GUANIDINE serves as a valuable precursor for the creation of a variety of complex organic molecules. Its reactivity and functional group compatibility make it suitable for use in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Research and Development:
N-(4-BROMO-PHENYL)-GUANIDINE is also utilized in research and development settings to explore its potential applications and to understand its chemical behavior. This can lead to the discovery of new uses and the optimization of existing processes involving this compound.

Upstream product

• 420-04-2 CYANAMID 
• 624-19-1 4-bromoaniline hydrochloride 
• 151-51-9 carbodiimide 
• 106-40-1 4-bromo-aniline 

Downstream Products

• 1226887-60-0 tert-butyl 2-(4-bromophenylamino)-4-hydroxy-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate 

Relevant articles and documents

DRUG CONJUGATES AND USES THEREOF

The invention generally relates to the design and production of drug conjugates, and specifically conjugates of antibiotic agents to cationic and non-cationic molecular transporters.

Guanidines

Novel substituted phenylquanidine compounds and processes for their preparation are disclosed. Their use as anti-hypertensive agents is also revealed.