67461-76-1Relevant articles and documents
One-step conversion of 2-Amino- N ′-arylbenzamidines into 3-aryl-4-imino-3,4-dihydroquinazoline-2-carbonitriles using 4,5-dichloro-1,2,3- dithiazolium chloride
Mirallai, Styliana I.,Manos, Manolis J.,Koutentis, Panayiotis A.
, p. 9906 - 9913 (2013/10/22)
2-Amino-N′-arylbenzamidines react with 4,5-dichloro-1,2,3- dithiazolium chloride (Appel salt) in the presence of Huenig's base (2 equiv) to give in one step 3-aryl-4-imino-3,4-dihydroquinazoline-2-carbonitriles in 53-81% yields. Nine examples are presented along with the single-crystal X-ray structure of 4-imino-3-phenyl-3,4-dihydroquinazoline-2-carbonitrile. Furthermore, the behavior of the latter toward both acid and base hydrolysis is investigated. All new compounds are fully characterized, and a mechanistic rationale for the formation of the iminoquinazolines is provided.
SUBSTITUENT EFFECTS ON THE RATE OF CYCLIZATION OF N-PHENYL-N'-(o-CYANOPHENYL)UREA IN SOLUTION
Vasil'eva, I. V.,Teleshov, E. N.,Pravednikov, A. N.
, p. 1319 - 1322 (2007/10/02)
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