13114-96-0Relevant academic research and scientific papers
The reaction of 2-(acylamino)benzonitriles with primary aromatic amines: A convenient synthesis of 2-substituted 4-(arylamino)quinazolines
Marinho, Elina,Proen?a, M. Fernanda
, p. 1623 - 1632 (2015)
Abstract 2-Substituted 4-(arylamino)quinazolines were prepared from 2-(acylamino)benzonitriles and primary arylamines by refluxing in either ethanol using trifluoroacetic acid as a catalyst or acetic acid. The 2-aminobenzonitrile was acylated by reaction with anhydrides, isocyanates, or ethyl chloroformate at room temperature.
T3P mediated intramolecular rearrangement of o-aminobenzamide to o-ureidobenzonitrile using isothiocyanates
Shamanth, Sadashivamurthy,Nagarakere, Sandhya C.,Sagar, Kunigal S.,Narayana, Yatheesh,Mamatha, Mahesha,Rangappa, Kanchugarakoppal S.,Kempegowda, Mantelingu
supporting information, p. 1197 - 1205 (2021/02/16)
Current work describes the environmentally benign approach for the synthesis of o-ureidobenzonitriles, from o-aminobenzamides and isothiocyanates using T3P. Here, the conversion of thiourea to urea and amide to nitrile take place simultaneously via unprec
I2-Catalyzed transformation of: O -aminobenzamide to o -ureidobenzonitrile using isothiocyanates
Chaithra, Nagaraju,Gurukiran, Mahesha,Lokanath, N. K.,Mamatha, Mahesha,Mantelingu, Kempegowda,Rangappa, Kanchugarakoppal S.,Shamanth, Sadashivamurthy
supporting information, p. 2678 - 2684 (2020/04/17)
The present work describes an unexpected and unique protocol for the iodine catalysed synthesis of o-ureidobenzonitriles using o-aminobenzamides and isothiocyanates via intramolecular rearrangement. The metal-free route achieved here is insensitive to moisture and applicable to the synthesis of a wide variety of o-ureidobenzonitriles with excellent yields even in a scalable fashion.
Ortho-substituent effects on diphenylurea packing motifs
Solomos, Marina A.,Watts, Taylor A.,Swift, Jennifer A.
, p. 5065 - 5072 (2018/03/01)
Hydrogen bonding between urea groups is a widely used motif in crystal engineering and supramolecular chemistry studies. In an effort to discern how the steric and electronic properties of substituents affect the molecular conformation and crystal packing
Controlling molecular tautomerism through supramolecular selectivity
Epa, Kanishka,Aakeroey, Christer B.,Desper, John,Rayat, Sundeep,Chandra, Kusum Lata,Cruz-Cabeza, Aurora J.
supporting information, p. 7929 - 7931 (2013/09/02)
We have isolated the stable as well as the metastable tautomers of 1-deazapurine in the solid state by exploiting principles of supramolecular selectivity in the context of cocrystal design.
