67473-46-5

Upstream product

• 4571-25-9 2-bromo-1-(2,5-dichlorophenyl)ethanone 
• 540-72-7 sodium thiocyanide 
• 123-30-8 4-amino-phenol 
• 1520-27-0 1-(4-hydroxyphenyl)thiourea 
• 7396-79-4 2-chloro-1-(2,5-dichloro-phenyl)-ethanone 

Relevant academic research and scientific papers

Synthesis and Biological Evaluation of N-aryl-4-aryl-1,3-Thiazole-2-Amine Derivatives as Direct 5-Lipoxygenase Inhibitors

Biological evaluation of N-aryl-4-aryl-1,3-thiazole-2-amine derivatives was examined for anti-inflammatory activity in in vitro and in vivo assays. The thiazole compounds showed direct inhibition of 5-lipoxygenase (LOX) that is a key enzyme of leukotrienes synthesis and involved in the inflammation-related diseases, including asthma and rheumatoid arthritis. To optimize biological activity, we synthesized 1,3-thiazole-2-amine derivatives and investigated for structure and activity relationship. Especially, N-(3,5-dimethylphenyl)-4-(4-chlorophenyl)-1,3-thiazole-2-amine was shown to have a potent anti-inflammatory activity as a 5-LOX inhibitor.