67475-55-2

Basic information

• Product Name: Benzenesulfonyl chloride, 3-fluoro-4-methoxy- (9CI)
• Synonyms: 3-fluoro-4-methoxybenzenesulfonyl chloride(SALTDATA: FREE);4-(Chlorosulphonyl)-2-fluoroanisole;3-Fluoro-4-methoxybenzenesulfonyl chloride 97%;Benzenesulfonyl chloride, 3-fluoro-4-methoxy- (9CI)
• CAS NO: 67475-55-2
• Molecular Formula: C₇H₆ClFO₃S
• Molecular Weight: 224.6371432
• Product Categories: Aryl Fluorinated Building Blocks;Building Blocks;C7;Chemical Synthesis;Fluorinated Building Blocks;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks;Sulfonyl Halides;Sulfur Compounds;SULFONYLHALIDE;Chemical Synthesis;New Products for Chemical Synthesis;Organic Building BlocksOrganic Building Blocks;Sulfonyl Halides;Sulfur Compounds
• Mol File: 67475-55-2.mol
• Article Data: 2

Chemical Properties

• Melting Point: 77-81 °C
• Boiling Point: 314.9°C at 760 mmHg
• Flash Point: 144.3°C
• Appearance: /
• Density: 1.455g/cm³
• Vapor Pressure: 0.000835mmHg at 25°C
• Refractive Index: 1.519
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive: Moisture Sensitive
• CAS DataBase Reference: Benzenesulfonyl chloride, 3-fluoro-4-methoxy- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonyl chloride, 3-fluoro-4-methoxy- (9CI)(67475-55-2)
• EPA Substance Registry System: Benzenesulfonyl chloride, 3-fluoro-4-methoxy- (9CI)(67475-55-2)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 3261 8/PG 2
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 67475-55-2(Hazardous Substances Data)

Usage

General Description

Benzenesulfonyl chloride, 3-fluoro-4-methoxy- (9CI) is a chemical compound used in organic synthesis and pharmaceutical research. It is a sulfonyl chloride derivative of benzenesulfonic acid, containing a fluorine atom at the 3-position and a methoxy group at the 4-position of the benzene ring. Benzenesulfonyl chloride, 3-fluoro-4-methoxy- (9CI) is commonly used as a reagent for the introduction of the sulfonyl group in organic molecules, and it can also be utilized in the synthesis of pharmaceuticals and agrochemicals. Its specific properties and functional groups make it a versatile and valuable building block for the production of a wide range of complex organic compounds.

InChI:InChI=1/C7H6ClFO3S/c1-12-7-3-2-5(4-6(7)9)13(8,10)11/h2-4H,1H3

Upstream product

• 321-28-8 1-fluoro-2-methoxybenzene 

Downstream Products

• 67475-18-7 N-(5-ethyl-[1,3,4]thiadiazol-2-yl)-3-fluoro-4-methoxy-benzenesulfonamide 
• 67475-50-7 3-fluoro-4-methoxy-N-(5-pentyl-[1,3,4]thiadiazol-2-yl)-benzenesulfonamide 
• 89818-27-9 3-fluoro-4-methoxybenzenethiol 
• 1314324-92-9 N-(4-methoxy-1H-benzo[d]imidazol-7-yl)-3-fluoro-4-methoxybenzenesulfonamide 
• 956467-53-1 (2S,5S)-1-{[3,4-bis(methyloxy)phenyl]sulfonyl}-4-{[3-fluoro-4-(methyloxy)phenyl]sulfonyl}-2,5-dimethylpiperazine 
• 956467-19-9 1-{[3,4-bis(methyloxy)phenyl]sulfonyl}-4-{[3-fluoro-4-(methyloxy) phenyl]sulfonyl}-2,6-cis-dimethylpiperazine 
• 956466-92-5 1-{[3,4-bis(methyloxy)phenyl]sulfonyl}-4-{[3-fluoro-4-(methyloxy)phenyl]sulfonyl}piperazine 
• 919081-47-3 N-[(1S,2R)-1-benzyl-3-[[(3-fluoro-4-methoxyphenyl)sulfonyl](isobutyl)amino]-2-hydroxypropyl]carbamic acid tert-butyl ester 
• 67475-44-9 3-fluoro-N-(5-isobutyl-[1,3,4]thiadiazol-2-yl)-4-methoxy-benzenesulfonamide 
• 67475-38-1 N-(5-butyl-[1,3,4]thiadiazol-2-yl)-3-fluoro-4-methoxy-benzenesulfonamide 
• 67475-31-4 3-fluoro-N-(5-isopropyl-[1,3,4]thiadiazol-2-yl)-4-methoxy-benzenesulfonamide 
• 67475-25-6 3-fluoro-4-methoxy-N-(5-propyl-[1,3,4]thiadiazol-2-yl)-benzenesulfonamide 

Relevant articles and documents

PLASMA KALLIKREIN INHIBITORS AND USES THEREOF

The present invention provides compounds and compositions thereof which are useful as inhibitors of plasma kallikrein and which exhibit desirable characteristics for the same.