674773-18-3Relevant academic research and scientific papers
Synthesis of new fused and spiro 1,5-benzodiazepines
Khodairy,Abdel-Ghany,El-Sayed,Salah
, p. 1195 - 1198 (2007/10/03)
[1,3-Dihydro-4-phenyl(1,5)benzodiazepin-2-ylidene]malononitrile 1, was treated with formaline and some different primary amines to give the corresponding pyrimido(1,5)benzodiazepines 2a-d. Treatment of compound 1a with halo reagents yielded the corresponding pyrrolobenzodiazepines 3a,b. The reaction of compound 1a with active methylenes, bidentates, S,S- and N,S-acetals afforded the corresponding spiro(1,5)benzodiazepines 4a-c-8a,b, respectively.
