16439-95-5

Usage

Uses

Used in Pharmaceutical Industry:
4-Phenyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one is used as a pharmaceutical drug for its potential anxiolytic and sedative effects, targeting the treatment of anxiety disorders and insomnia. Its specific structure allows for targeted interactions with biological systems, potentially offering therapeutic benefits in managing these conditions.
Used in Research and Development:
In the field of medicinal chemistry, 4-Phenyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one serves as a valuable compound for research and development. Its unique structure provides a basis for exploring new drug candidates and understanding the mechanisms of action within the benzodiazepine class, potentially leading to the discovery of novel therapeutic agents with improved efficacy and safety profiles.
Used in Drug Design and Synthesis:
4-Phenyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one is utilized in drug design and synthesis processes to create new benzodiazepine-based compounds with tailored properties. By modifying its structure, chemists can optimize its pharmacological activity, selectivity, and pharmacokinetic profile, resulting in the development of more effective and safer drugs for various therapeutic applications.
Used in Neuropharmacology:
In the study of neuropharmacology, 4-Phenyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one is employed as a research tool to investigate the mechanisms underlying the anxiolytic and sedative effects of benzodiazepines. Understanding its interactions with neurotransmitter systems and receptors can provide insights into the development of new treatments for neurological and psychiatric disorders.

InChI:InChI=1/C15H12N2O/c18-15-10-14(11-6-2-1-3-7-11)16-12-8-4-5-9-13(12)17-15/h1-9H,10H2,(H,17,18)

Upstream product

• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 95-54-5 1,2-diamino-benzene 
• 67259-20-5 2-(4-methyl-1-piperazinyl)-4-phenyl-3H-1,5-benzodiazepine 
• 50850-07-2 2-methylthio-4-phenyl-3H-1,5-benzodiazepine 
• 50-01-1 guanidine hydrochloride 
• 66752-03-2 3-bromo-2-oxo-4-phenyl-2,3-dihydro-1H-1,5-benzodiazepine 
• 17356-08-0 thiourea 
• 41054-45-9 4-phenyl-1,3-dihydro-2H-1,5-benzodiazepine-2-thione 
• 115749-28-5 hydroxyamino-2 phenyl-4 benzodiazepine-1,5 
• 55991-67-8 5-phenylfuran-2,3-dione 
• 614-27-7 methyl 3-oxo-3-phenylpropionate 
• 77092-12-7 6-phenyl-2,2-dimethyl-1,3-dioxin-4-one 
• 115749-29-6 phenyl-3 N-(amino-2 phenyl)amino-5 isoxazole 
• 1076-59-1 3-phenyl-4H-isoxazol-5-one 

Downstream Products

• 82040-02-6 3-chloro-4-(p-chlorophenyl)-2,3-dihydro-1H-1,5-benzodiazepin-2-one 
• 122773-90-4 1,5-diacetyl-4-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one 
• 95-54-5 1,2-diamino-benzene 
• 16442-59-4 5-acetyl-4-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one 
• 1009636-71-8 3-cyano-1,11-dihydro-4,5-diphenyl-2-thioxopyrido[2,3-b](1,5)-benzodiazepine 
• 1009636-94-5 1-cyano-1,10-dihydro-2-oxo-4-phenylthieno[3,2-b](1,5)benzodiazepine 
• 1009636-93-4 2-amino-1-carbethoxy-4-phenyl-10(H)-thieno[3,2-b](1,5)benzodiazepine 
• 1272323-21-3 4-phenyl-10H-isoxazolo[5,4-b](1,5)benzodiazepine 
• 1272323-06-4 3-cyano-5-phenyl-2,11-dihydro-1H-pyrido[2,3-b]-1,5-benzodiazepin-2-one 
• 1272323-09-7 3-cyano-5-phenyl-2,11-dihydro-1H-pyrido[2,3-b]-1,5-benzodiazepine-2-thione 
• 1272323-11-1 10-amino-8-oxo-12-phenyl-8,9-dihydro-5H-[1,6]naphthyridino[2,3-b]-1,5-benzodiazepine-7-carbonitrile 
• 1272323-12-2 C₂₄H₁₈N₄O₄ 
• 1272323-13-3 5-phenylpyrido[2,3-b]-1,5-benzodiazepine 
• 1272323-15-5 3-[(1,3,4-triazol-5-yl)aminomethylene]-4-phenyl-1,3-dihydro-2H-1,5-benzodiazepin-2-one 

Relevant academic research and scientific papers

Analgesic and antioxidant activities of 4-phenyl-1,5-benzodiazepin-2-one and its long carbon chains derivatives

The aim of this work is to deepen the pharmacological effect of 4-phenyl-1,5-benzodiazepin-2-one derivatives which have a similar structure to nonionic surfactants: 4-phenyl-1,5-benzodiazepin-2-one is the hydrophilic head, and the carbon chain is hydropho

Reaction of 1,3-dicarbonyl compounds with o-phenylenediamine or 3,3′-diaminobenzidine in water or under solvent-free conditions via microwave irradiation

Reaction of o-phenylenediamine with β-diketones or β-ketoesters in water formed 2-substituted benzimidazoles. Reaction of 3,3′- diaminobenzidine gave similar results. Under microwave irradiation conditions solvent-free reaction of o-phenylenediamine with β-ketoesters afforded 1,5-benzodiazepin-2-one derivatives. An exception is the reaction of o-phenylenediamine with ethyl acetoacetate under microwave irradiation, which gave 2-methylbenzimidazole.

Hetaryl-1,5 Benzodiazepines—Part I: Synthesis of 3-pyrimidinyl- and Imidazolyl-1,5-benzodiazepines

Nucleophilic substitution of 3-bromo-4-phenyl-1H-[1,5]benzodiazepin-2-one (1) with thiourea or guanidine in presence of potassium carbonate afforded 1,5-benzodiazepin-3-ylimidothiocarbamate 2 or 1,5-benzodiazepin-3-ylguanidine 3, respectively. Pyrimidylthiobenzodiazepines 5, 6, 7, 8, 9, 10, 11, 12, 13 were obtained via the reaction of compound 2 with malononitrile dimer, diethyl malonate, methylenemalononitriles, or a mixture of an aldehyde and β-keto esters or acetylacetone, catalyzed using ceric ammonium nitrate. Reaction of compound 2 or 3 with α-halo esters, nitriles, and/or ketones afforded imidazoles 14, 15, 16, 17, 18, 19, 20, respectively.

Asymmetric Hydrogenation of Cyclic Imines of Benzoazepines and Benzodiazepines with Chiral, Cationic Ruthenium–Diamine Catalysts

A method for the highly enantioselective hydrogenation of diverse seven-membered N-containing heterocycles, including 2,4-diaryl-3H-benzo[b]azepines, racemic 2,2,4-trisubstituted 2,3-dihydrobenzo[b][1,4]diazepines, and 4-substituted 1H-benzo[b][1,4]diazep

1,5-Benzodiazepin-2-ones: Investigation of a Family of Photoluminescent Materials

Photoluminescent materials, that are now ubiquitous in our everyday life, have particularly attracted the attention of the scientific community these past few years due to potential important applications such as in bioimaging, sensing, or optoelectronics

COMPOUNDS WHICH HAVE A PROTECTIVE ACTIVITY WITH RESPECT TO THE ACTION OF TOXINS AND OF VIRUSES WITH AN INTRACELLULAR MODE OF ACTION

The subject matter of the present invention is novel families of compounds which are aromatic amine, imine, aminoadamantane and benzodiazepine derivatives, medicaments comprising same and the use thereof as inhibitors of the toxic effects of toxins with intracellular activity, such as, for example, ricin, and of viruses that use the internalization pathway for infecting cells.

GPR17 Receptor Modulators

Chemical compounds are provided which act on GPR17 receptors and are useful in the treatment or amelioration of chronic and/or acute neurodegenerative diseases, such as multiple sclerosis, inflammatory diseases, pathologies involving the immune system, cardiovascular diseases, and renal diseases.

GPR17 RECEPTOR MODULATORS

The present invention relates to chemical compounds acting through GPR17 receptor for use in the treatment o f diseases, in particular for use in chronic and/or acute neurodegenerative diseases, preferably Multiple Sclerosis, inflammatory diseases, pathologies involving the immune system, cardiovascular diseases, renal diseases.

INHIBITORS OF THE SHIGA TOXINS TRAFFICKING THROUGH THE RETROGRADE PATHWAY

The present invention relates to the use of compounds of general formula (I) and (II) for the preparation of a drug for preventing and/or treating disorders caused by Shiga toxins and related toxins.

Organocatalyzed one-pot synthesis of substituted 1,5-benzodiazepine and benzimidazole derivatives

An efficient synthesis of some heterocycles is described by condensation between o-phenylenediamine and 1,3-dicarbonyl compounds catalyzed by L-proline. The reaction is carried out either at room temperature or reflux depending on the substrates. Copyright