674773-25-2

Upstream product

• 374728-19-5 N-[2-(3-methoxy-4-(prop-2-ynyloxy)phenyl)ethyl]formamide 
• 528594-30-1 2-methoxy-4-(2-nitroethyl)phenol 
• 637359-33-2 4-(2-isocyanoethyl)-2-methoxy-1-(prop-2-ynyloxy)benzene 
• 282721-32-8 N-[2-(4-hydroxy-3-methoxyphenyl)ethyl]formamide 
• 22568-51-0 (E)-2-methoxy-4-(2-nitrovinyl)phenol 
• 554-52-9 3-Methoxytyramine 

Relevant academic research and scientific papers

Multicomponent reactions in fungicide research: The discovery of mandipropamid

Isocyanide-based multicomponent reactions of the Ugi- and Passerini-type have been valuable tools for the rapid exploration of the novel fungicidal compound classes of phenylglycinamides and mandelamides. Mandipropamid (6), which was discovered during this derivatisation, displays excellent activity against the economically important phytopathogens Phytophthora infestans (potato and tomato late blight) and Plasmopara viticola (grape downy mildew).

N-sulfonyl amino acid amides, a novel class of compounds with fungicidal activity [1]

Novel types of oomycete fungicides have been designed and prepared. The synthetic approach to these N-sulfonyl amino acid amides is outlined. Bioassays demonstrate their high efficacy against important plant diseases like Phytophthora infestans (tomato and potato late blight) and Plasmopara viticola (grape downy mildew). Structure-activity relationship studies are discussed.