674777-74-3

Upstream product

• 1125-88-8 benzaldehyde dimethyl acetal 
• 17042-40-9 4-methoxyphenyl 2,3,4,6-tetra-O-acetyl-1-α-D-mannopyranoside 
• 28541-75-5 p-methoxyphenyl α-D-mannopyranoside 
• 100-52-7 benzaldehyde 

Downstream Products

• 1140963-84-3 4-methoxyphenyl 3-O-benzyl-4,6-O-benzylidene-α-D-mannopyranoside 
• 123826-52-8 p-methoxyphenyl 3,6-di-O-benzyl-α-D-mannopyranoside 
• 351011-70-6 p-methoxyphenyl 2-O-benzoyl-3,6-di-O-benzyl-α-D-mannopyranosyde 
• 1644133-95-8 4-methoxyphenyl-2-O-benzoyl-4,6-O-benzylidene-α-D-mannopyranoside 
• 674777-75-4 p-methoxyphenyl-4,6-O-benzylidene-2,3-O-benzyl-α-D-mannopyranoside 
• 674777-78-7 C₆₄H₆₆O₁₂ 
• 674777-76-5 p-methoxyphenyl-2,3,6-tri-O-benzyl-4-propargyl-α-D-mannopyranoside 
• 126403-23-4 p-methoxyphenyl 2,3,6-tri-O-benzyl-α-D-mannopyranoside 

Relevant academic research and scientific papers

Synthesis method of core structure of O-mannan

The invention belongs to the field of synthesis of saccharide substances, and particularly relates to a synthesis method of the core structure of O-mannan. Conventional research indicates that alpha-DG O-mannan is relevant with a mechanism of diseases of

Total Synthesis of Mannopeptimycins α and β

The mannopeptimycins are a class of glycopeptide natural products with unusual structures and potent antibiotic activity against a range of Gram-positive multidrug-resistant bacteria. Their cyclic hexapeptide core features a pair of unprecedented β-hydroxyenduracididines (l- and d-βhEnd), an O-glycosylated d-Tyr carrying an α-linked dimannose, and a β-methylated Phe residue. The d-βhEnd unit also carries an α-linked mannopyranose at the most hindered N of its cyclic guanidine ring. Herein, we report the first total synthesis of mannopeptimycin α and β with fully elaborated N- and O-linked sugars. Critically, a gold-catalyzed N-glycosylation of a d-βhEnd substrate with a mannosyl ortho-alkynylbenzoate donor enabled the synthesis of the most challenging N-Man-d-βhEnd unit with excellent efficiency and stereoselectivity. The l-βMePhe unit was prepared using a Pd-catalyzed C-H arylation method. The l-βhEnd, d-Tyr(di-Man), and l-βMePhe units were prepared in gram quantities. A convergent assembly of the cyclic peptide scaffold and a single global hydrogenolysis deprotection operation provided mannopeptimycin α and β.

Efficient convergent synthesis of Bi-, Tri-, and tetra-antennary complex type N-glycans and their HIV-1 antigenicity

The structural diversity of glycoproteins often comes from post-translational glycosylation with heterogeneous N-glycans. Understanding the complexity of glycans related to various biochemical processes demands a well-defined synthetic sugar library. We r

Synthesis of Readily Modifiable Cyclodextrin Analogues via Cyclodimerization of an Alkynyl-Azido Trisaccharide

A convergent strategy for the synthesis of β-cyclodextrin analogues is reported, utilizing preferential cyclodimerization of an azido-alkyne trisaccharide via Cu(I)-catalyzed [3 + 2] dipolar cycloaddition of the alkyne and azide functional groups. The res