674782-29-7Relevant articles and documents
Preparation method of
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, (2021/10/27)
The preparation method comprises the following steps: taking a halogen-containing azide compound as a raw material in γ-position, carrying out a reaction, and preparing and a derivative thereof. The method is characterized in γ-position halogen-containing azide compound as a raw material and is subjected to reduction. A series of non-sequential reactions, such as hydrolysis, substitution, condensation, reductive amination, and the like. A target compound, that is, a Mahalanobis derivative, can be obtained. The preparation method has the advantages of mild reaction conditions, simplicity and convenience in operation, low cost, less side reaction, high product purity, simplicity and convenience in separation and purification and the like. The invention further provides the pulvernolol and derivatives thereof prepared by the method and application thereof.
METHOD FOR PREPARING MARAVIROC
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, (2019/08/26)
Provided is a method for preparing a tropane derivative, maraviroc, including reacting a compound of formula (II) with a compound of formula (I), wherein the compound of formula (II) is prepared by the steps of acetylation of a compound of formula (III), activation and substitution of a compound of formula (IV) by a chlorination agent, cyclization of a compound of formula (V), and debenzylation of a compound of formula (VI) by hydrogenation. Hence, the present disclosure provides a method for preparing maraviroc with good yield and simple operation.
Asymmetric Mannich Reaction and Construction of Axially Chiral Sulfone-Containing Styrenes in One Pot from α-Amido Sulfones Based on the Waste-Reuse Strategy
Li, Dongmei,Tan, Yu,Peng, Lei,Li, Shan,Zhang, Nan,Liu, Yidong,Yan, Hailong
, p. 4959 - 4963 (2018/08/24)
A simultaneous asymmetric Mannich reaction and the construction of axially chiral sulfone-containing styrenes in one pot from α-amido sulfones based on the waste-reuse strategy was demonstrated. A series of chiral β-amino diesters and axially chiral sulfone-containing styrenes with various functional groups were synthesized in good to excellent yields and enantioselectivities under mild conditions. In addition, this protocol has been successfully applied to synthesize the anti-HIV drug Maraviroc and chiral trichloro derivatives.