674793-32-9

Basic information

• Product Name: 5-chloro-2-fluorobenzamidine
• Synonyms: 5-chloro-2-fluorobenzimidamide hydrochloride;BenzenecarboxiMidaMide, 5-chloro-2-fluoro-;5-chloro-2-fluoroBenzenecarboximidamide;5-chloro-2-fluorobenzamidine;5-chloro-2-fluorobenzimidamide;2-Fluoro-5-chlorobenzamidine
• CAS NO: 674793-32-9
• Molecular Formula: C₇H₆ClFN₂
• Molecular Weight: 172.59
• Mol File: 674793-32-9.mol

Chemical Properties

• Boiling Point: 255℃
• Flash Point: 108℃
• Appearance: /
• Density: 1.41
• Vapor Pressure: 0.017mmHg at 25°C
• Refractive Index: 1.577
• CAS DataBase Reference: 5-chloro-2-fluorobenzamidine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-2-fluorobenzamidine(674793-32-9)
• EPA Substance Registry System: 5-chloro-2-fluorobenzamidine(674793-32-9)

Safety Data

• Hazardous Substances Data: 674793-32-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5-chloro-2-fluorobenzamidine is used as a synthetic intermediate for the development of various pharmaceuticals. Its unique structure with chlorine and fluorine substituents, along with the amidine functional group, allows for the creation of diverse drug molecules with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 5-chloro-2-fluorobenzamidine is utilized as a precursor in the synthesis of pesticides. Its chemical properties enable the production of effective compounds for pest control and management in agriculture, contributing to increased crop yields and protection against harmful organisms.
Used in Chemical Research:
5-chloro-2-fluorobenzamidine also serves as a valuable compound in chemical research, particularly in the exploration of new synthetic pathways and the development of novel chemical entities. Its unique structural features make it an interesting candidate for studying various chemical reactions and mechanisms, potentially leading to the discovery of new applications and uses in different fields.

InChI:InChI=1/C7H6ClFN2/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3H,(H3,10,11)

Upstream product

• 57381-34-7 5-chloro-2-fluorobenzonitrile 
• 4039-32-1 lithium hexamethyldisilazane 

Downstream Products

• 674793-70-5 2-(5-chloro-2-fluorobenzyl)-5-cyclopropyl-pyrimidone 
• 773140-40-2 2-(5-chloro-2-fluorophenyl)-5-methyl-6,7-dihydro-5H-cyclopentapyrimidin-4-ol 
• 773140-05-9 C₁₃H₁₁ClFN₃O 
• 859173-98-1 2-(5-chloro-2-fluoro-phenyl)-7-fluoro-3H-pyrido[2,3-d]pyrimidin-4-one 
• 674793-63-6 2-(5-chloro-2-fluoro)-5-cyclobutylpyrimidine-4-one 
• 674793-54-5 2-(5-chloro-2-fluorophenyl)-5-isopropylpyrimidine-4-one 
• 773140-01-5 C₁₃H₁₁ClFN₃O 
• 911700-96-4 6-(5-chloro-2-fluorophenyl)-3-cyclopentyl-1H-pyrimidin-2-one 
• 773140-36-6 2-(5-chloro-2-fluorophenyl)-6,7-dihydrofuro[3,2-d]pyrimidin-4-ol 
• 773140-30-0 2-(5-chloro-2-fluorophenyl)-5,7-dihydrofuro[3,4-d]pyrimidin-4-ol 
• 773139-99-4 C₁₃H₁₀ClFN₂O 
• 859173-98-1 2-(5-chloro-2-fluoro-phenyl)-7-fluoro-pyrido[2,3-d]pyrimidin-4-ol 
• 859174-12-2 C₁₄H₉ClFN₃O₂ 
• 674793-81-8 C₁₆H₁₁ClFN₅O₃ 

Relevant articles and documents

CARBOXAMIDE 4-[(4-PYRIDYL)AMINO]PYRIMIDINES USEFUL AS HCV INHIBITORS

The present invention relates to the use of carboxamide 4-[(4-pyridyl)amino]- pyrimidines as inhibitors of HCV replication as well as their use in pharmaceutical compositions aimed to treat or combat HCV infections.

HETEROBICYLIC INHIBITORS OF HCV

Fused bicyclic pyrimidine compounds having an amide-substituted pyridylamine group at C-4 of the pyrimidine of formula (I) ring are useftul in the treatment of conditions associated with HCV.

CARBOXAMIDE INHIBITORS OF TGFB

Certain appropriately substituted forms of pyrimidine having a pyridylamine group at C- 4 of the pyrimidine and an amide group on the pyridine ring are useful in the treatment of conditions associated with excessive TGFB activity.

INHIBITORS OF TFGβ

Certain appropriately substituted forms of pyrimidine and triazine are useful in the treatment to conditions associated with enhanced TGFβ activity.