674795-26-7Relevant academic research and scientific papers
8-substituted O 6-cyclohexylmethylguanine CDK2 inhibitors: Using structure-based inhibitor design to optimize an alternative binding mode
Carbain, Benoit,Paterson, David J.,Anscombe, Elizabeth,Campbell, Allyson J.,Cano, Celine,Echalier, Aude,Endicott, Jane A.,Golding, Bernard T.,Haggerty, Karen,Hardcastle, Ian R.,Jewsbury, Philip J.,Newell, David R.,Noble, Martin E. M.,Roche, Celine,Wang, Lan Z.,Griffin, Roger J.
, p. 56 - 70 (2014)
Evaluation of the effects of purine C-8 substitution within a series of CDK1/2-selective O6-cyclohexylmethylguanine derivatives revealed that potency decreases initially with increasing size of the alkyl substituent. Structural analysis showed
