6749-93-5

Usage

Uses

Used in Pharmaceutical Industry:
Cyclopropylmethyl 4-nitrobenzoate is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of various biologically active compounds.
Used in Agrochemical Industry:
Cyclopropylmethyl 4-nitrobenzoate is used as an intermediate in the synthesis of agrochemicals, playing a role in the creation of substances that can help control, prevent, or kill pests in agriculture.
Used in Organic Chemistry:
Cyclopropylmethyl 4-nitrobenzoate is used as a building block in organic chemistry, particularly in the synthesis of various biologically active compounds, due to its stability and enhanced reactivity.

Upstream product

• 2516-33-8 Cyclopropylmethanol 
• 122-04-3 4-nitro-benzoyl chloride 
• 13277-61-7 p-Nitrobenzoyl bromide 
• 555-16-8 4-nitrobenzaldehdye 
• 62-23-7 4-nitro-benzoic acid 

Relevant academic research and scientific papers

Aerobic oxidative esterification and thioesterification of aldehydes using dibromoisocyanuric acid under mild conditions: No metal catalysts required

A practical direct method for the direct preparation of esters and thioesters from aldehydes is described. Esters and thioesters were synthesized by oxidative esterification and thioesterification via in situ generated acyl bromide intermediates, which were used to react with various alcohols and thiols. The esterification and thioesterification were readily performed in the presence of dibromoisocyanuric acid in dichloromethane, without any metal catalysts and under mild conditions. By using this reaction protocol, various esters and thioesters were prepared in high yields. This effective method offers a promising approach for the facile esterification and thioesterification of aldehydes.

Determining the σ-donor ability of the cyclopropane C-C bond

The low temperature crystal structures of ester and ether derivatives of varying electron demand, derived from cyclopropylmethanol 8 and dicyclopropylmethanol 9, have been determined. These structures show a very strong response of the C-OR bond distance to the electron demand of the OR substituent, demonstrating the strong σ-donor ability of the strained C-C bonds in the cyclopropane ring. The Royal Society of Chemistry 2005.