675198-19-3

Usage

Chemical Properties

white powder

Upstream product

• 37699-43-7 2,3-dimethyl-4-nitropyridine N-oxide 
• 59886-90-7 4-chloro-2,3-dimethylpyridine-N-oxide 
• 117977-18-1 2,3-dimethyl-4-(3-methoxypropoxy)pyridine nitroxide 

Downstream Products

• 117976-89-3 rabeprazole 
• 117977-21-6 rabeprazole sulfide 
• 117977-20-5 2-chloromethyl-4-(3-methoxy propyloxy)-3-methyl pyridine 
• 117976-90-6 Rabeprazole sodium 

Relevant academic research and scientific papers

Preparation method of 2-hydroxymethyl-4-(methoxypropoxy)-3-methylpyridine hydrochloride

The invention relates to a preparation method of 2-hydroxymethyl-4-(methoxypropoxy)-3-methylpyridine hydrochloride. The method comprises the following steps: reacting an initial raw material 2,3-dimethyl-4-chloropyridine-N-oxide hydrochloride with 3-methoxypropanol under a solvent-free condition to obtain 2,3-dimethyl-4-(methoxypropoxy)-pyridine-N-oxide, acetylizing the 2,3-dimethyl-4-(methoxypropoxy)-pyridine-N-oxide, hydrolyzing the acetylized 2,3-dimethyl-4-(methoxypropoxy)-pyridine-N-oxide, and carrying out a salt formation reaction to obtain the 2-hydroxymethyl-4-(methoxypropoxy)-3-methylpyridine hydrochloride. The purity of 2-hydroxymethyl-4-(methoxypropoxy)-3-methylpyridine hydrochloride solid can reach 98% or above, and 2-chloromethyl-4-(methoxypropoxy)-3-methylpyridine obtained after a chlorination reaction of 2-hydroxymethyl-4-(methoxypropoxy)-3-methylpyridine hydrochloride can directly react with 2-mercaptobenzimidazole without a salt formation or purification process in order to prepare rabeprazole thioether; and the solid has good stability, has no strict requirements on transportation or storage conditions, can be stored for a long time, and is suitable for being used as a rabeprazole sodium intermediate.

Diversified synthesis of novel quinoline and dibenzo thiazepine derivatives using known active intermediates

The novel drug development to control resisting infections in conventional drug therapy is a need of today. Few antiulcer relative derivatives developed by approaching convergent synthesis. The derivatives synthesized successfully are dibenzo thiazepine-pyridine (SLN11-SLN15) and benzimidazole-hydroquinoline based derivatives (SLN16-SLN20). It involved the coupling through microwave, sonication and conventional techniques at final step. The efficient technology identified as sonication technique basically time and yield. The reported compounds were structural characterized by elemental analysis and spectral studies such as 1H, 13C NMR and MS.