6753-55-5Relevant articles and documents
Treatment of age-related memory impairment
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Page/Page column 7-8, (2008/06/13)
Symptoms, including biochemical correlates, of age-related memory loss (ARML) in a mammal are beneficially affected by administering to the mammal small doses of bodies, such as liposomes, of a size resembling that of mammalian cells, the bodies having phosphate glycerol head groups presented exteriorly on their surfaces. Preferred are liposomes comprised of 50-100% phosphatidylglycerol, with the phosphoglycerol headgroups thereof exteriorly presented.
Synthesis of Benzophenone-Containing Analogues of Phosphatidylcholine
Wang, Pingzhen,Blank, David H.,Spencer, Thomas A.
, p. 2693 - 2702 (2007/10/03)
As part of a collaborative study of cellular efflux of cholesterol and phospholipids, photoactivable analogues 4-8 of phosphatidylcholine (PC) having benzophenone groups in the choline moiety and at the end of the C2 and C1 alkyl chains have been synthesized. The efficient preparation via Suzuki coupling of the appropriate long-chain benzophenone-containing carboxylic acid and alcohol and their incorporation by adaptation of known approaches into the acyl- and ether-linked PC analogues 6-8 are described. Development of a method for radiolabeling these PC analogues, via hydrogenation of a double bond in modified side chains, is also described.
Synthesis of a small library of mixed-acid phospholipids from D-mannitol as a homochiral starting material
Xia, Jie,Hui, Yong-Zheng
, p. 1659 - 1663 (2007/10/03)
Synthesis of a series of mixed-acid phospholipids containing a polyunsaturated fatty acid using a newly protecting strategy are described. Thus, benzyl and methyl α-(2,4-dinitrophenyl)acetic acid which were respectively removed by BCl3 and 354 nm light are used as protecting groups.
Method of lowering the viscosity of mucus
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, (2008/06/13)
The use of phospholipids of the following formula to reduce the viscosity of mucus in a patient is described: STR1 wherein one of X, Y, or Z represent: STR2 in which each R represents hydrogen or methyl, and each of the other two of X, Y, or Z represents --CO--R1 in which R1 represents linear or branched C11-21 alkyl or C11-21 alkenyl, unsubstituted or substituted with one or more substituents selected from the group consisting of halo, C1-6 linear or branched alkoxy or cyano.
Liposome-Mediated Enzymatic Synthesis of Phosphatidylcholine as an Approach to Self-Replicating Liposomes
Schmidli, Peter Kurt,Schurtenberger, Peter,Luisi, Pier Luigi
, p. 8127 - 8130 (2007/10/02)
The four enzymes of the salvage pathway for phosphatidylcholine synthesis sn-glycerol-3-phosphate acyltransferase, 1-acyl-sn-glycerol-3-phosphate acyltransferase, phosphatidate phosphatase, and cytidinediphosphocholine phosphocholinetransferase were simul
Single-stage process for preparing mixed-substituted 1,2-diacyl-sn-clycero-3-phosphocholines
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, (2008/06/13)
Single-stage process for preparing mixed-substituted enantiomerically pure 1,2-diacyl-sn-glycero-3-phosphocholines of general formula I STR1 in which R1 and R2 are different and independently of each other denote a substituted or uns
Derivatives of glycerophosphocholine and glycerophosphoethanolamine, their preparation and their use
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, (2008/06/13)
The invention relates to new triphenylmethyl derivatives of sn-glycero-3-phosphocholine and sn-glycero-3-phosphoethanolamine of the general formula STR1 in which T denotes a triphenylmethyl group which is unsubstituted or monosubstituted or polysubstitute