103634-10-2

Basic information

• Product Name: [R-(Z)]-4-Hydroxy-N,N,N-triMethyl-9-oxo-7-[(triphenylMethoxy)Methyl]-3,5,8-trioxa-4-phosphahexacos-17-en-1-aMiniuM 4-Oxide Inner Salt
• Synonyms: [R-(Z)]-4-Hydroxy-N,N,N-triMethyl-9-oxo-7-[(triphenylMethoxy)Methyl]-3,5,8-trioxa-4-phosphahexacos-17-en-1-aMiniuM 4-Oxide Inner Salt;(7R,17Z)-4-Hydroxy-N,N,N-triMethyl-9-oxo-7-[(triphenylMethoxy)Methyl]-3,5,8-trioxa-4-phosphahexacos-17-en-1-aMiniuM 4-Oxide Inner Salt;[R-(Z)]-4-Hydroxy-N,N,N-trimethyl-9-oxo-7-[(triphenylmethoxy)methyl]-3,5,8-trioxa-4-phosphahexacos-17-en-1-aminium inner salt 4-oxide
• CAS NO: 103634-10-2
• Molecular Formula: C₄₅H₆₆NO₇P
• Molecular Weight: 764
• Product Categories: Fatty Acid Derivatives & Lipids;Glycerols;Phosphorylcholine Derivatives;Glycerols, Fatty Acid Derivatives & Lipids, Phosphorylcholine Derivatives
• Mol File: 103634-10-2.mol

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility: Methanol, Tetrahydrofuran
• CAS DataBase Reference: [R-(Z)]-4-Hydroxy-N,N,N-triMethyl-9-oxo-7-[(triphenylMethoxy)Methyl]-3,5,8-trioxa-4-phosphahexacos-17-en-1-aMiniuM 4-Oxide Inner Salt(CAS DataBase Reference)
• NIST Chemistry Reference: [R-(Z)]-4-Hydroxy-N,N,N-triMethyl-9-oxo-7-[(triphenylMethoxy)Methyl]-3,5,8-trioxa-4-phosphahexacos-17-en-1-aMiniuM 4-Oxide Inner Salt(103634-10-2)
• EPA Substance Registry System: [R-(Z)]-4-Hydroxy-N,N,N-triMethyl-9-oxo-7-[(triphenylMethoxy)Methyl]-3,5,8-trioxa-4-phosphahexacos-17-en-1-aMiniuM 4-Oxide Inner Salt(103634-10-2)

Safety Data

• Hazardous Substances Data: 103634-10-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
[R-(Z)]-4-Hydroxy-N,N,N-triMethyl-9-oxo-7-[(triphenylMethoxy)Methyl]-3,5,8-trioxa-4-phosphahexacos-17-en-1-aMiniuM 4-Oxide Inner Salt is used as an intermediate in the synthesis of glycerophospholipids for its role in regulating enzyme activities. This makes it a valuable component in the development of pharmaceuticals targeting various diseases and conditions.
Used in Biochemical Research:
In the field of biochemical research, [R-(Z)]-4-Hydroxy-N,N,N-triMethyl-9-oxo-7-[(triphenylMethoxy)Methyl]-3,5,8-trioxa-4-phosphahexacos-17-en-1-aMiniuM 4-Oxide Inner Salt is utilized for studying the mechanisms of enzyme regulation and the role of glycerophospholipids in cellular processes. This helps researchers gain a deeper understanding of biological systems and develop new therapeutic strategies.
Used in Cosmetics Industry:
[R-(Z)]-4-Hydroxy-N,N,N-triMethyl-9-oxo-7-[(triphenylMethoxy)Methyl]-3,5,8-trioxa-4-phosphahexacos-17-en-1-aMiniuM 4-Oxide Inner Salt may also find applications in the cosmetics industry, where it can be used as an active ingredient in skincare products. Its role in enzyme regulation and its potential effects on cellular processes could contribute to the development of innovative cosmetic formulations with anti-aging, moisturizing, or other beneficial properties.

Upstream product

• 103675-56-5 1-O-trityl-sn-glycero-3-phosphocholine 
• 64833-92-7 oleoylimidazole 
• 112-80-1 cis-Octadecenoic acid 
• 76-83-5 trityl chloride 
• 28319-77-9 L-glycero-3-phosphorylcholine 

Downstream Products

• 6753-55-5 2-oleoyl-1-palmitoyl-sn-glycero-3-phosphocholine 

Relevant articles and documents

Synthesis of phosphatidylcholines containing ricinoleic acid

1,2-Diricinoleoyl- and 1-ricinoleoyl-2-oleoyl-sn-glycero-3-phosphocholine were synthesised with good yields. The synthesis started with the preparation of ricinoleic acid from castor oil. The choice of a suitable agent to protect the -OH group of ricinoleic acid was a key factor to afford the final products. Several protecting groups were assayed but only β-methoxyethoxymethyl chloride (MEMCl) and 2,2,2-trichloroethyl chloroformate (TRECCl) gave reasonable yields and good optical purities of the final products. The overall yields for 1,2-diricinoleoyl-sn-glycero-3-phosphocholine and 1-ricinoleoyl-2-oleoyl-sn-glycero-3-phosphocholine were 32.1% (with respect to ricinoleic acid methyl ester using TREC as protecting group) and 10.3% (with respect to 1-trityl-glycero-3-phosphocholine), respectively.

Synthesis of Benzophenone-Containing Analogues of Phosphatidylcholine

As part of a collaborative study of cellular efflux of cholesterol and phospholipids, photoactivable analogues 4-8 of phosphatidylcholine (PC) having benzophenone groups in the choline moiety and at the end of the C2 and C1 alkyl chains have been synthesized. The efficient preparation via Suzuki coupling of the appropriate long-chain benzophenone-containing carboxylic acid and alcohol and their incorporation by adaptation of known approaches into the acyl- and ether-linked PC analogues 6-8 are described. Development of a method for radiolabeling these PC analogues, via hydrogenation of a double bond in modified side chains, is also described.