675574-51-3Relevant articles and documents
Syntheses and insecticidal activities of novel 2,5-disubstituted 1,3,4-oxadiazoles
Zheng, Xiumian,Li, Zhong,Wang, Yanli,Chen, Weidong,Huang, Qingchun,Liu, Chuanxiang,Song, Gonghua
, p. 163 - 169 (2007/10/03)
Nine novel symmetrical and asymmetrical 2,5-disubstituted 1,3,4-oxadiazoles have been synthesized by a facile and mild method with high yield. Meantime, it was found that the fluorine was easy substituted by hydrazine in polyhalogen-substituted aroyl hydrazine. The preliminary bioassay tests show that two of the compounds (D5> and D6) exhibited a significant insecticidal activity (LC50=116.02 and 70.93 mg l-1) on armyworm, Leucania separata Walker. Using the Drug Discovery Workbench (DDW) (Cerius2), structure-activities relationship was studied.