6756-33-8

Usage

Chemical class

Nitrofuran derivatives

Main use

Antimicrobial agent

Spectrum of activity

Broad-spectrum (against bacteria, fungi, and protozoa)

Common treatment areas

Genitourinary and gastrointestinal tracts

Specific infections treated

Urinary tract infections, bacterial vaginosis, and giardiasis

Mechanism of action

Inhibition of nucleic acid synthesis in microorganisms

Safety profile

Generally considered safe and well-tolerated

Resistance risk

Low risk of developing resistance

Upstream product

• 50832-67-2 1-acetyl-2-[2-(5-nitro-furan-2-yl)-vinyl]-1H-imidazole 
• 698-63-5 5-nitrofurane-2-carboxaldehyde 

Relevant academic research and scientific papers

N-substituted 2-[2-(5-nitro-2-furyl) vinyl]imidazoles

N-substituted 2-[2-(5-nitro-2-furyl)vinyl]imidazoles having the structure STR1 wherein R represents mono- or dimethoxybenzyl, pyridylmethyl, N,N-dimethylaminobenzyl or phenoxypropyl. A preferred compound is 1-(4-methoxybenzyl)-2-[2-(5-nitro-2-furyl)vinyl]imidazole. The compounds have utility as antischistosomal chemotherapeutic agents.

Chemotherapeutic nitroheterocycles. Antischistosomal properties of nitrofurylvinyl and nitrothienylvinyl heterocycles

A series of 24 analogs of the experimental antischistosomal agent, 5 amino 3 [2 (5 nitro 2 furyl) vinyl] 1,2,4 oxadiazole, was prepared and evaluated in mice infected with Schistosoma mansoni. Although antischistosomal activity was widespread in the series, only four of the compounds showed significant curative properties. Compounds containing 2 imidazolyl and 2 pyridyl groups gave cure rates around 25% at 400 and 250 mg/kg dose levels, respectively. The 2 thiazolyl and 2 pyrimidyl derivatives were especially notable, yielding 100% cures at 250 and 200 mg/kg dose levels, respectively.