675615-58-4

Upstream product

• 675615-54-0 3-(4-fluorobenzyl)-8-hydroxy-5-iodo[1,6]naphthyridine-7-carboxylic acid methyl ester 
• 100-39-0 benzyl bromide 

Downstream Products

• 675615-90-4 methyl 5-acetyl-8-benzyloxy-3-(4-fluorobenzyl)[1,6]naphthyridine-7-carbonate 
• 862508-97-2 methyl 8-benzyloxy-3-(4-fluorobenzyl)-5-methyl[1,6]naphthyridine-7-carbonate 
• 675616-01-0 8-benzyloxy-3-(4-fluorobenzyl)-5-iodo[1,6]naphthyridine-7-carboxylic acid 
• 675615-59-5 C₂₆H₂₁FN₂O₅ 

Relevant academic research and scientific papers

NAPHTHYLIDINE DERIVATIVE HAVING HIV INTEGRASE INHIBITORY ACTIVITY

[Problems to be Solved] To provide a novel compound having antiviral activity, especially inhibitory activity against HIV integrase, a pharmaceutical composition, especially anti-HIV drug, containing the same. [Means to Solve the Problem] A compound of th

HETEROCYCLIC COMPOUND HAVING HIV INTEGRASE INHIBITORY ACTIVITY

A heterocyclic compound of the formula (I): wherein B1 is -C(R2)= or -N=; R1' is H, etc.; one of R1 and R2 is -Z1-Z2-Z3-R5 wherein Z1 and Z3 are independently single bond, optionally substituted alkylene, etc.; Z2 is single bond, optionally substituted alkylene, etc.; R5 is optionally substituted aryl, optionally substituted heteroaryl, etc., and the other of R1 and R2 is H; -A1- is -C(-Y)=C(-RA)-C(-R3)=C(-R4)-, etc. wherein Y is OH, etc.; RA is -COR7 wherein R7 is OH, etc.; one of R3 and R4 is carboxy, etc., and the other of R1 and R2 is H, etc, a prodrug thereof, a pharmaceutically acceptable salt thereof, and a solvate thereof, having an antiviral activity, more particularly, an inhibitory activity against HIV integrase, and a pharmaceutical composition containing the same, especially an anti-HIV drug.