67576-51-6Relevant articles and documents
Azetidinone derivatives, a process for their preparation and their use as intermediates in the preparation of carbapenem antibiotics
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, (2008/06/13)
Compounds of formula (I): STR1 (wherein R1 represents hydrogen or a hydroxy-protecting group, R2 and R3 represent hydrogen, alkyl or aryl; R4 represents optionally substituted alkyl, alicyclic heterocyclic, aryl
Olivanic Acid Analogues. Part 8. Halogenation and Sulphenylation Reactions leading Selectively to cis-Carbapenem Precursors; Stereospecific Synthesis of (+/-)-6-Epithienamycin
Bateson, John H.,Robins, Alison M.,Southgate, Robert
, p. 29 - 35 (2007/10/02)
Introduction of halogen or sulphenyl substituents at C-7 of ketone 1, followed by stereospecific reduction steps, provides a selective route either to the (6RS,7RS,9RS) isomer 11 or to the (6RS,7RS,9SR) isomer 14 of 7-(1-hydroxyethyl)-8-oxo-3-oxa-1-azabic
Studies on the Syntheses of Heterocyclic Compounds. Part 877. An Alternative Synthesis of Protected (+/-)-Thienamycin and a Related Compound
Kametani, Tetsuji,Huang, Shyh-Pyng,Nagahara, Takayasu,Yokohama, Shuichi,Ihara, Masataka
, p. 964 - 968 (2007/10/02)
An alternative total synthesis of protected (+/-)-thienamycin (2) and an analogue is described. (+/-)-4β-(2,2-Dimethoxyethyl)-3α-*)-1-(-nitrobenzyloxycarbonyloxy)ethyl>azetidin-2-one (5), prepared from isoxazoline derivatives (4), was conve
Total Synthesis of (+/-)-Epithienamycins A and B and Derivatives
Kametani, Tetsuji,Huang, Shyh-Pyng,Nagahara, Takayasu,Ihara, Masataka
, p. 2282 - 2286 (2007/10/02)
(+/-)-(3R*,4R*)-4-(2,2-Dimethoxyethyl)-3-*)-1-hydroxyethyl>azetidin-2-one (7), which has been stereoselectively synthesised via the 4-methoxycarbonylisoxazoline (4), was converted into (+/-)-epithienamycins A (2) and B
Thienamycin Total Synthesis. 3. Total Synthesis of (+/-)-Thienamycin and (+/-)-8-Epithienamycin
Schmitt, Susan M.,Johnston, David B.R.,Christensen, B.G.
, p. 1142 - 1148 (2007/10/02)
The completion of the total synthesis of (+/-)-8-epithienamycin and (+/-)-thienamycin from azetidinones 3a and 3b using the methodology developed for the synthesis of model compound 4 (see part 2) is described.