65750-52-9

Upstream product

• 4457-32-3 4-nitrobenzyl chloroformate 
• 72447-82-6 trans-4-methoxycarbonyl-3-(2',2'-dimethoxyethyl)-5-methylisoxazoline 
• 73844-78-7 trans-3-(2',2'-dimethoxyethyl)-5-methylisoxazoline-4-carboxylic acid 
• 72447-85-9 trans-4-<(2',2'-dimethoxy)ethyl>-3-<(1'R)-hydroxyethyl>azetidin-2-one 
• 72447-85-9 trans-3-(1'-hydroxyethyl)-4-(2',2'-dimethoxyethyl)-2-azetidinone 
• 72447-84-8 methyl 3-amino-5-hydroxy-1,1-dimethoxyhexane-4-carboxylate 
• 78522-77-7 (S)-3-Amino-2-((R)-1-hydroxy-ethyl)-5,5-dimethoxy-pentanoic acid 
• 65750-59-6 2-(4-nitrobenzyloxycarbonylamino)ethanethiol 
• 72789-82-3 (+/-)-4β-(2',2'-dimethoxyethyl)-3α-((1'R*)-p-nitrobenzyloxycarbonyloxyethyl)-2-azetidinone 
• 72789-82-3 trans-4-(2',2'-dimethoxyethyl)-3-(1'-p-nitrobenzyloxycarbonyloxyethyl)-2-azetidinone 
• 65794-42-5 Carbonic acid (R)-1-[(2S,3R)-2-(2-hydroxy-ethyl)-4-oxo-azetidin-3-yl]-ethyl ester 4-nitro-benzyl ester 
• 67314-42-5 Carbonic acid 4-nitro-benzyl ester (R)-1-[(3R,4S)-2-oxo-4-(2-oxo-ethyl)-azetidin-3-yl]-ethyl ester 

Downstream Products

• 65750-60-9 2-Chloro-2-{(2S,3S)-2-{(E)-2-[2-(4-nitro-benzyloxycarbonylamino)-ethylsulfanyl]-vinyl}-3-[(S)-1-(4-nitro-benzyloxycarbonyloxy)-ethyl]-4-oxo-azetidin-1-yl}-malonic acid bis-(4-nitro-benzyl) ester 
• 65750-61-0 2-Hydroxy-2-{(2S,3S)-2-{(E)-2-[2-(4-nitro-benzyloxycarbonylamino)-ethylsulfanyl]-vinyl}-3-[(S)-1-(4-nitro-benzyloxycarbonyloxy)-ethyl]-4-oxo-azetidin-1-yl}-malonic acid bis-(4-nitro-benzyl) ester 
• 65750-61-0 2-Hydroxy-2-{(2S,3S)-2-{(Z)-2-[2-(4-nitro-benzyloxycarbonylamino)-ethylsulfanyl]-vinyl}-3-[(S)-1-(4-nitro-benzyloxycarbonyloxy)-ethyl]-4-oxo-azetidin-1-yl}-malonic acid bis-(4-nitro-benzyl) ester 
• 65750-53-0 2-{(2S,3S)-2-{(E)-2-[2-(4-Nitro-benzyloxycarbonylamino)-ethylsulfanyl]-vinyl}-3-[(S)-1-(4-nitro-benzyloxycarbonyloxy)-ethyl]-4-oxo-azetidin-1-yl}-malonic acid bis-(4-nitro-benzyl) ester 
• 65750-54-1 (4S,5R,6R)-4-Bromo-3-[2-(4-nitro-benzyloxycarbonylamino)-ethylsulfanyl]-6-[(R)-1-(4-nitro-benzyloxycarbonyloxy)-ethyl]-7-oxo-1-aza-bicyclo[3.2.0]heptane-2,2-dicarboxylic acid bis-(4-nitro-benzyl) ester 
• 65750-55-2 (5R,6R)-3-[2-(4-Nitro-benzyloxycarbonylamino)-ethylsulfanyl]-6-[(R)-1-(4-nitro-benzyloxycarbonyloxy)-ethyl]-7-oxo-1-aza-bicyclo[3.2.0]hept-3-ene-2,2-dicarboxylic acid bis-(4-nitro-benzyl) ester 
• 67576-51-6 (5R,6S)-3-[2-(4-Nitro-benzyloxycarbonylamino)-ethylsulfanyl]-6-[(S)-1-(4-nitro-benzyloxycarbonyloxy)-ethyl]-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester 
• 72778-06-4 (2S,5S,6S)-3-[2-(4-Nitro-benzyloxycarbonylamino)-ethylsulfanyl]-6-[(S)-1-(4-nitro-benzyloxycarbonyloxy)-ethyl]-7-oxo-1-aza-bicyclo[3.2.0]hept-3-ene-2-carboxylic acid 4-nitro-benzyl ester 
• 72749-11-2 6-Eth-(Z)-ylidene-3-[2-(4-nitro-benzyloxycarbonylamino)-ethylsulfanyl]-7-oxo-1-aza-bicyclo[3.2.0]hept-3-ene-2,2-dicarboxylic acid bis-(4-nitro-benzyl) ester 
• 72765-22-1 6-Eth-(E)-ylidene-3-[2-(4-nitro-benzyloxycarbonylamino)-ethylsulfanyl]-7-oxo-1-aza-bicyclo[3.2.0]hept-3-ene-2,2-dicarboxylic acid bis-(4-nitro-benzyl) ester 
• 67245-93-6 Carbonic acid 4-nitro-benzyl ester (R)-1-((2R,3R)-2-{(E)-2-[2-(4-nitro-benzyloxycarbonylamino)-ethylsulfanyl]-vinyl}-4-oxo-azetidin-3-yl)-ethyl ester 

Relevant academic research and scientific papers

Studies on the Syntheses of Heterocyclic Compounds. 800. A Formal Total Synthesis of (+/-)-Thienamycin and (+/-)-Decysteaminylthienamycin Derivative

The synthesis of a key intermediate for the preparation of (+/-)-thienamycin (1) and its derivatives has been developed.By 1,3-dipolar cycloaddition, the nitrile oxide derived from 3-nitropropanal dimethyl acetal (3) was added to methyl crotonate to give

Thienamycin Total Synthesis. 3. Total Synthesis of (+/-)-Thienamycin and (+/-)-8-Epithienamycin

The completion of the total synthesis of (+/-)-8-epithienamycin and (+/-)-thienamycin from azetidinones 3a and 3b using the methodology developed for the synthesis of model compound 4 (see part 2) is described.