675833-69-9Relevant academic research and scientific papers
The discovery of glycine and related amino acid-based factor Xa inhibitors
Kohrt, Jeffrey T.,Filipski, Kevin J.,Cody, Wayne L.,Bigge, Christopher F.,La, Frances,Welch, Kathleen,Dahring, Tawny,Bryant, John W.,Leonard, Daniele,Bolton, Gary,Narasimhan, Lakshmi,Zhang, Erli,Peterson, J. Thomas,Haarer, Staci,Sahasrabudhe, Vaishali,Janiczek, Nancy,Desiraju, Shrilakshmi,Hena, Mostofa,Fiakpui, Charles,Saraswat, Neerja,Sharma, Raman,Sun, Shaoyi,Maiti, Samarendra N.,Leadley, Robert,Edmunds, Jeremy J.
, p. 4379 - 4392 (2007/10/03)
Herein, we report on the identification of three potent glycine and related amino acid-based series of FXa inhibitors containing a neutral P1 chlorophenyl pharmacophore. A X-ray crystal structure has shown that constrained glycine derivatives with optimiz
INHIBITORS OF FACTOR XA AND OTHER SERINE PROTEASES INVOLVED IN THE COAGULATION CASCADE
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Page 64, (2010/02/06)
This invention discloses amino acid derivatives which display inhibitory effects on the serine protease factor Xa. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, methods for the preparation of the compounds, and methods of using them as therapeutic agents for treating or preventing disease states in mammals characterized by abnormal thrombosis.
