67585-98-2

Upstream product

• 34286-66-3 N-benzyloxycarbonyl-(R)alanyl-glycine 
• 38155-45-2 methyl L-phenylalanyl-L-leucinate hydrochloride 
• 3986-23-0 (S)-2-((S)-2-Amino-3-phenyl-propionylamino)-4-methyl-pentanoic acid methyl ester; hydrobromide 
• 26607-51-2 N-benzyloxycarbonyl-D-alanine 
• 83945-01-1 N-benzyloxycarbonyl-(R)alanyl-glycine methyl ester 

Downstream Products

• 83892-15-3 (R)alanyl-glycyl-(S)phenylalanyl-(S)leucine methyl ester 
• 83891-93-4 L-tyrosyl-D-alanylglycyl-L-phenylalanyl-L-leucine N-methylamide 
• 85148-73-8 L-tyrpsyl-D-alanylglycyl-L-phenylalanyl-L-leucine hydrazide 
• 83891-97-8 N-benzyloxycarbonyl-L-tyrosyl-D-alanylglycyl-L-phenylalanyl-L-leucine N-methylamine 
• 83892-16-4 N-benzyloxycarbonyl-L-tyrosyl-D-alanylglycyl-L-phenylalanyl-L-leucine methyl ester 
• 85148-72-7 N-benzyloxycarbonyl-L-tyrosyl-D-alanylglycyl-L-phenylalanyl-L-leucine hydrazide 
• 83891-98-9 N-benzyloxycarbonyl-L-tyrosyl-D-alanylglycyl-L-phenylalanyl-L-leucine 2-aminoethylamide 
• 83544-70-1 L-tyrosyl-D-alanylglycyl-L-phenylalanyl-L-leucine 2-aminoethylamide 
• 145763-51-5 (S)-2-{(S)-2-[2-((R)-2-{2-Benzyloxycarbonylamino-3-[4-(toluene-4-sulfonyloxy)-phenyl]-propionylamino}-propionylamino)-acetylamino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid methyl ester 
• 145763-41-3 N-benzyloxycarbonyl-O-tosyl-(Z)dehydrotyrosyl-(R)alanyl-glycyl-(S)phenylalanyl-(S)leucine methyl ester 

Relevant academic research and scientific papers

DIASTEREOSELECTIVE HYDROGENATION OF MONODEHYDRO ENKEPHALINS CONTROLLED BY CHIRAL RHODIUM CATALYSTS

Protected (Z)dehydrophenylalanyl-Leu-enkephalin, (Z)dehydrotyrosyl-Leu-enkephalin and (Z)dehydrotyrosyl-(R)Ala2-Leu-enkephalin, have been synthesized.These compounds have been hydrogenated to give protected Leu-enkephalins in the presence of various chiral rhodium complexes.Deprotection of the product gave Leu-enkephalins or epimers, ytterbium in liquid ammonia allows smooth deprotection of NHCBz or OTs groups on small amounts of peptides.Strong stereocontrol could be achieved by suitable choice of the chiral catalyst.This method has good potential for stereospecific labelling of enkephalins and other small peptides.

OPIOID-LIKE PEPTIDES. PART I. HYDRAZIDE AND SOME AMIDES OF 2-Leu-ENKEPHALIN

Synthesis and pharmacological properties of hydrazide, methylamide, 2-aminoethylamide, dimethylamide and butylamide of 2-Leu-enkephalin are described.