675855-60-4

Upstream product

• 358-23-6 trifluoromethylsulfonic anhydride 
• 20056-73-9 4-undecylphenol 
• 5355-17-9 4-hydroxybenzyl methyl ether 
• 675855-49-9 1-ethoxymethoxy-4-methoxymethylbenzene 
• 675855-56-8 1-ethoxymethoxy-4-undecylbenzene 
• 14850-23-8 trans-4-Octene 
• 179548-39-1 4-(3-iodopropyl)phenol 
• 10210-17-0 3-(4-hydroxyphenyl)propan-1-ol 

Relevant academic research and scientific papers

NiH-Catalyzed Reductive Relay Hydroalkylation: A Strategy for the Remote C(sp3)?H Alkylation of Alkenes

The terminal-selective, remote C(sp3)?H alkylation of alkenes was achieved by a relay process combining NiH-catalyzed hydrometalation, chain walking, and alkylation. This method enables the construction of unfunctionalized C(sp3)?C(sp3) bonds under mild conditions from two simple feedstock chemicals, namely olefins and alkyl halides. The practical value of this transformation is further demonstrated by the large-scale and regioconvergent alkylation of isomeric mixtures of olefins at low catalyst loadings.

Reductive lithiation of alkoxy-substituted benzyl methyl ethers and connection with cross-coupling reactions

2-and 4-Ethoxymethoxybenzyl methyl ethers were employied as useful starting materials for the synthesis of 1,2- or 1,4-dicarbo-substituted benzenes. The proposed reaction sequence involves connection between the reductive lithiation of benzyl alkyl ethers and the metal-catalyzed cross-coupling reaction of aromatic triflates.