675872-24-9Relevant academic research and scientific papers
Improved asymmetric synthesis of dopamine D1 full agonist, dihydrexidine, employing chiral ligand-controlled asymmetric conjugate addition of aryllithium to a nitroalkene
Yamashita, Mitsuaki,Yamada, Ken-Ichi,Tomioka, Kiyoshi
, p. 4237 - 4242 (2007/10/03)
Asymmetric conjugate addition of 2-trityloxymethylpheyllithium to a nitroalkene was mediated by a chiral ligand to give the key intermediate for dopamine D1 full agonist dihydrexidine 1. The shortcut of both Curtius rearrangement and Pictet-Spengler type
Construction of Arene-Fused-Piperidine Motifs by Asymmetric Addition of 2-Trityloxymethylaryllithiums to Nitroalkenes: The Asymmetric Synthesis of a Dopamine D1 Full Agonist, A-86929
Yamashita, Mitsuaki,Yamada, Ken-Ichi,Tomioka, Kiyoshi
, p. 1954 - 1955 (2007/10/03)
The straightforward methodology for the construction of chiral arene-fused-piperidine motifs using a highly enantioselective addition of 2-trityloxymethylaryllithiums to cyclic and acyclic nitroalkenes has been developed. The versatility of the process wa
