174691-84-0Relevant articles and documents
The first asymmetric synthesis of a dopamine D1 agonist, dihydrexidine, employing asymmetric conjugate addition technology
Asano, Yasutomi,Yamashita, Mitsuaki,Nagai, Kazushige,Kuriyama, Masami,Yamada, Ken-Ichi,Tomioka, Kiyoshi
, p. 8493 - 8495 (2001)
The first asymmetric synthesis of benzophenanthridine dopamine D1 full agonist, dihydrexidine, was accomplished employing three key processes, external chiral ligand-controlled conjugate addition of phenyllithium, Curtius conversion of a carboxylic group
Improved asymmetric synthesis of dopamine D1 full agonist, dihydrexidine, employing chiral ligand-controlled asymmetric conjugate addition of aryllithium to a nitroalkene
Yamashita, Mitsuaki,Yamada, Ken-Ichi,Tomioka, Kiyoshi
, p. 4237 - 4242 (2007/10/03)
Asymmetric conjugate addition of 2-trityloxymethylpheyllithium to a nitroalkene was mediated by a chiral ligand to give the key intermediate for dopamine D1 full agonist dihydrexidine 1. The shortcut of both Curtius rearrangement and Pictet-Spengler type