67598-46-3Relevant academic research and scientific papers
Direct conversion of carboxylic acids to various nitrogen-containing compounds in the one-pot exploiting curtius rearrangement
Kumar, Arun,Kumar, Naveen,Sharma, Ritika,Bhargava, Gaurav,Mahajan, Dinesh
, p. 11323 - 11334 (2019/09/10)
Herein we report, a single-pot multistep conversion of inactivated carboxylic acids to various N-containing compounds using a common synthetic methodology. The developed methodology rendered the use of carboxylic acids as a direct surrogate of primary amines, for the synthesis of primary ureas, secondary/tertiary ureas, O/S-carbamates, benzoyl ureas, amides, and N-formyls, exploiting the Curtius reaction. This approach has a potential to provide a diversified library of N-containing compounds, starting from a single carboxylic acid, based on the selection of the nucleophile.
Darstellung von Carbonsaeure-dihalogenphosphorsaeure-anhydriden
Effenberger, Franz,Koenig, Gerd
, p. 916 - 925 (2007/10/02)
The mixed anhydrides 3, 4, 6, and 7 are prepared in good yields by conproportionation of the respective carboxylic and dihalophosphoric anhydrides 1 and 2.The aryl derivatives 3 and 4 can be isolated in neat form, the alkyl compounds 6 and 7 undergo further reactions upon destillation.For the combination of trihaloacetic and dihalophosphoric anhydrides, the equilibrium is shifted to the side of the symmetrical anhydrides (5d, e and 2).
