67604-85-7

Downstream Products

• 13484-60-1 inosine 5'-monophosphate 
• 212714-91-5 (S)-4-Benzyloxycarbonylamino-5-[((2R,3S,4R,5R)-3,4-dihydroxy-5-purin-9-yl-tetrahydro-furan-2-ylmethoxy)-methoxy-phosphoryloxy]-pentanoic acid benzyl ester 
• 212714-87-9 (S)-4-Benzyloxycarbonylamino-5-[((3aR,4R,6R,6aR)-2,2-dimethyl-6-purin-9-yl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethoxy)-methoxy-phosphoryloxy]-pentanoic acid benzyl ester 

Relevant academic research and scientific papers

A 15N-STUDY ON THE DEAMINATION OF 1-AMINOPURINIUM SALTS WITH AMINES

Reaction of 1-aminoadenosinium mesitylenesulphonate, 1a, with methanolic ammonia for 10 h at 80 deg C yields adenosine, 7a, and nebularine, 6a.With methanolic methylamine 1a gives 6-methylamino-9-β-D-ribofuranosylpurine, 8a, and adenosine, 7a, respectively.Similar results are obtained with the salt of 1-amino-2',3'-O-isopropylideneadenosine, 1b. 1-Aminoadeninium mesitylenesulphonate, 1c, with methanolic methylamine only yields 6-(methylamino)purine, 8c.In contrast, the mesitylenesulphonate salt of 1,2-diaminopurine, 11, with methanolic methylamine gives only deamination at N1, affording 2-aminopurine, 12.Studies with 15N-labelled methanolic ammonia or 15N-labelled purinium compounds show that in all these reactions, except that of 11, a ring-opening mechanism (ANRORC-mechanism) is involved.