6761-52-0

Usage

Uses

Used in Organic Synthesis:
3-Aminopyrazine-2-carbohydrazide is utilized as a reagent in organic synthesis, particularly for the preparation of pharmaceuticals and agrochemicals. Its unique structure and reactivity contribute to the synthesis of a variety of compounds with potential therapeutic and agricultural benefits.
Used in Catalyst Production for Polymer Synthesis:
In the polymer industry, 3-aminopyrazine-2-carbohydrazide serves as a catalyst in the production of polymers. Its catalytic properties facilitate the formation of polymers with specific characteristics, enhancing the efficiency and versatility of polymer synthesis processes.
Used as a Precursor in Organic Chemistry:
3-Aminopyrazine-2-carbohydrazide also functions as a precursor to other organic compounds, allowing for the creation of a diverse range of chemical entities. Its role as a precursor is crucial in the development of new materials and compounds with specialized applications.
Used in Biochemical Research:
3-Aminopyrazine-2-carbohydrazide has demonstrated potential as an inhibitor of certain enzymes, making it a valuable tool in biochemical research. Its ability to modulate enzyme activity can provide insights into biological processes and contribute to the development of new therapeutic agents.

Upstream product

• 32587-10-3 3-aminopyrazine-2-carboxamide 
• 5424-01-1 3-aminopyrazinoic acid 
• 16298-03-6 Methyl 3-amino-2-pyrazinecarboxylate 

Relevant academic research and scientific papers

Recursive partitioning analysis and anti-tubercular screening of 3- aminopyrazine-2-carbohydrazide derivatives

Background: Treating tuberculosis is a challenge due to the development of drug resistance. Hence, it is imperative to develop novel leads having high potency and efficacy to curb drug resistance. Methods: The present research work is focused on microwave

Synthesis and docking studies of pyrazine-thiazolidinone hybrid scaffold targeting dormant tuberculosis

The persistence of Mycobacterium tuberculosis (MTB) in dormant stage assists the pathogen to develop resistance against current antimycobactrial drugs. To address this issue, we report herein the synthesis of N-(4-oxo-2 substituted thiazolidin-3yl) pyrazi

Discovery of 1-(4-(5-(5-amino-6-(5-tert-butyl-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)-1-ethyl-1,2,4-triazol-3-yl)piperidin-1-yl)-3-hydroxypropan-1-one (AZD8835): A potent and selective inhibitor of PI3Kα and PI3Kδ for the treatment of cancers

Starting from potent inhibitors of PI3Kα having poor general kinase selectivity (e.g., 1 and 2), optimisation of this series led to the identification of 25, a potent inhibitor of PI3Kα (wild type, E545K and H1047R mutations) and PI3Kδ, selective versus PI3Kβ and PI3Kγ, with excellent general kinase selectivity. Compound 25 displayed low metabolic turnover and suitable physical properties for oral administration. In vivo, compound 25 showed pharmacodynamic modulation of AKT phosphorylation and near complete inhibition of tumour growth (93% tumour growth inhibition) in a murine H1047R PI3Kα mutated SKOV-3 xenograft tumour model after chronic oral administration at 25 mg/kg b.i.d. Compound 25, also known as AZD8835, is currently in phase I clinical trials.

CHEMICAL COMPOUNDS

The invention concerns compounds of Formula (I) or pharmaceutically-acceptable salts thereof, wherein R1 and R2 have any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of cell proliferative disorders.

CHEMICAL COMPOUNDS

The invention concerns compounds of Formula (I) (Formula (I)) or pharmaceutically-acceptable salts thereof, wherein R1 and R2 have any of the meanings defined herein before in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of cell proliferative disorders.

The synthesis of 3-amino-pyrazine-2-carbohydrazide and 3-Amino-N'- methylpyrazine-2-carbohydrazide derivatives

In research of new biologically active compounds, the reactions of amino-pyrazin-2-hydrazide and methylhydrazide with isothiocyanates, aromatic aldehydes, ketones, CS2, and formic acid were made. New thiosemicarbazides, 1,3,4-thiadiazoles, 1,3,4-oxadiazoles, and 1,2,4-triazoles were obtained. New 4-oxopteridine derivative 26 was also synthesized.