676135-18-5Relevant academic research and scientific papers
Facile synthesis of the glucosylceramide synthase inhibitor GZ667161
Hewlett, Elizabeth D.,Melenski, Edward,Qiu, Frederick V.,Leung, Hiu T.,Jacobson, Marlene,Qiu, Feng,Abou-Gharbia, Magid,Childers, Wayne
, (2020/09/10)
GZ667161 (GZ-161) is a quinuclidine-based small molecule inhibitor of the lysosomal enzyme glucosylceramide synthase. It represents an important tool molecule for studying the contribution of glycosphingolipids to disease pathology in lysosomal storage di
GLUCOSYLCERAMIDE SYNTHASE INHIBITORS
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Page/Page column 123, (2015/06/25)
The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy.
Glucosylceramide synthase inhibitors
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Page/Page column 50, (2015/09/28)
The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.
2-AMINO- AND 2-THIO-SUBSTITUTED 1,3-DIAMINOPROPANES
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Page/Page column 190, (2008/06/13)
Disclosed are compounds of the formula: where variables Q, Z, X, R15, R2, R3, and Rc are defined herein. Compounds disclosed herein are inhibitors of the beta-secretase enzyme and are therefore useful in the treatment of Alzheimer’s disease and other diseases characterized by deposition of A beta peptide in a mammal.
