64798-50-1Relevant academic research and scientific papers
Facile synthesis of the glucosylceramide synthase inhibitor GZ667161
Hewlett, Elizabeth D.,Melenski, Edward,Qiu, Frederick V.,Leung, Hiu T.,Jacobson, Marlene,Qiu, Feng,Abou-Gharbia, Magid,Childers, Wayne
, (2020/09/10)
GZ667161 (GZ-161) is a quinuclidine-based small molecule inhibitor of the lysosomal enzyme glucosylceramide synthase. It represents an important tool molecule for studying the contribution of glycosphingolipids to disease pathology in lysosomal storage di
Imidazo-fused oxazolo[4,5-b]pyridine and imidazo-fused thiazolo[4,5-b]pyridine based tricyclic compounds and pharmaceutical compositions comprising same
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Page/Page column 30, (2010/11/30)
The present invention provides for pyrazolopurine-based tricyclic compounds having the formula (I), wherein R1, R2, R3, and R6 are as described herein. The present invention further provides pharmaceutical compositions comprising such compounds, as well as the use of such compounds for treating inflammatory and immune diseases.
